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NMR Observation of Sulfhydryl Signals in SARS‐CoV‐2 Main Protease Aids Structural Studies

The 68‐kDa homodimeric 3C‐like protease of SARS‐CoV‐2, M(pro) (3CL(pro)/Nsp5), is a key antiviral drug target. NMR spectroscopy of this large system proved challenging and resonance assignments have remained incomplete. Here we present the near‐complete (>97 %) backbone assignments of a C145A var...

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Detalles Bibliográficos
Autores principales:	Robertson, Angus J., Ying, Jinfa, Bax, Ad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537880/ https://www.ncbi.nlm.nih.gov/pubmed/35972230 http://dx.doi.org/10.1002/cbic.202200471

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