Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination

Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV‐19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic‐clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV‐19 vac...

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Autores principales: Ahn, Seon‐Jae, Lee, Soon‐Tae, Chu, Kon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537891/
https://www.ncbi.nlm.nih.gov/pubmed/36053935
http://dx.doi.org/10.1002/acn3.51659
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author Ahn, Seon‐Jae
Lee, Soon‐Tae
Chu, Kon
author_facet Ahn, Seon‐Jae
Lee, Soon‐Tae
Chu, Kon
author_sort Ahn, Seon‐Jae
collection PubMed
description Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV‐19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic‐clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV‐19 vaccine. Clinical presentation and magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) test results were compatible with limbic encephalitis. Synaptic autoantibody tests confirmed serum and CSF GABA B receptor antibodies were present. The patient was treated with immunotherapy with intravenous immunoglobulin and rituximab. This GABA‐B receptor antibody encephalitis case occurred presumably due to transient autoantibody production following vaccine administration.
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spelling pubmed-95378912022-10-11 Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination Ahn, Seon‐Jae Lee, Soon‐Tae Chu, Kon Ann Clin Transl Neurol Case Study Several cases of autoimmune encephalitis have been reported after ChAdOx1 nCoV‐19 (AZD1222) vaccination. We encountered a male patient who presented with generalized tonic‐clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV‐19 vaccine. Clinical presentation and magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) test results were compatible with limbic encephalitis. Synaptic autoantibody tests confirmed serum and CSF GABA B receptor antibodies were present. The patient was treated with immunotherapy with intravenous immunoglobulin and rituximab. This GABA‐B receptor antibody encephalitis case occurred presumably due to transient autoantibody production following vaccine administration. John Wiley and Sons Inc. 2022-09-02 /pmc/articles/PMC9537891/ /pubmed/36053935 http://dx.doi.org/10.1002/acn3.51659 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Study
Ahn, Seon‐Jae
Lee, Soon‐Tae
Chu, Kon
Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
title Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
title_full Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
title_fullStr Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
title_full_unstemmed Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
title_short Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
title_sort postvaccinal gaba‐b receptor antibody encephalitis after chadox1 ncov‐19 vaccination
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537891/
https://www.ncbi.nlm.nih.gov/pubmed/36053935
http://dx.doi.org/10.1002/acn3.51659
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