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Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation of lipoylated mitochondrial proteins and the instability of Fe-S cluster proteins. However, the role of cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has n...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538148/ https://www.ncbi.nlm.nih.gov/pubmed/36212138 http://dx.doi.org/10.3389/fgene.2022.972212 |
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author | Zhu, Hongfei Mao, Feifei Wang, Kang Feng, Jinkai Cheng, Shuqun |
author_facet | Zhu, Hongfei Mao, Feifei Wang, Kang Feng, Jinkai Cheng, Shuqun |
author_sort | Zhu, Hongfei |
collection | PubMed |
description | Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation of lipoylated mitochondrial proteins and the instability of Fe-S cluster proteins. However, the role of cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has not been clearly elucidated. In this study, we identified and characterized cuproptosis-related lncRNAs in HCC. 343 HCC cases from The Cancer Genome Atlas (TCGA) with gene transcriptome data and clinical data were obtained for analysis after the screening. Univariate and multivariate Cox proportional hazards analyses were performed to establish a prognostic cuproptosis-related lncRNA signature (CRlncSig). We established a prognosis-related model consisting of nine cuproptosis-related lncRNAs: GSEC, AL158166.1, AC005479.2, AL365361.1, AC026412.3, AL031985.3, LINC00426, AC009974.2, AC245060.7, which was validated in the internal cohort. High-risk group stratified by the CRlncSig was significantly related to poor prognosis (p < 0.001). The area under the receiver operating characteristic curve (AUC) of 1 year, 3 years, and 5 years of survival were 0.813, 0.789, and 0.752, respectively. Furthermore, a prognostic nomogram including CRlncSig with clinicopathologic factors was built with favorable predictive power. In addition, GO and KEGG enrichment analysis suggested that CRlncSig was involved in many carcinogenesis and immune-related pathways. Additionally, we found that tumor microenvironment, immune infiltration, immune function, and drug response were significantly different between the high-risk and low-risk groups based on the risk model. These results highlight the value of cuproptosis-related lncRNAs on prognosis for HCC patients and provide insight into molecular and immune features underlying cuproptosis-related lncRNAs, which might play an important role in patient management and immunotherapy. |
format | Online Article Text |
id | pubmed-9538148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95381482022-10-08 Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma Zhu, Hongfei Mao, Feifei Wang, Kang Feng, Jinkai Cheng, Shuqun Front Genet Genetics Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation of lipoylated mitochondrial proteins and the instability of Fe-S cluster proteins. However, the role of cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has not been clearly elucidated. In this study, we identified and characterized cuproptosis-related lncRNAs in HCC. 343 HCC cases from The Cancer Genome Atlas (TCGA) with gene transcriptome data and clinical data were obtained for analysis after the screening. Univariate and multivariate Cox proportional hazards analyses were performed to establish a prognostic cuproptosis-related lncRNA signature (CRlncSig). We established a prognosis-related model consisting of nine cuproptosis-related lncRNAs: GSEC, AL158166.1, AC005479.2, AL365361.1, AC026412.3, AL031985.3, LINC00426, AC009974.2, AC245060.7, which was validated in the internal cohort. High-risk group stratified by the CRlncSig was significantly related to poor prognosis (p < 0.001). The area under the receiver operating characteristic curve (AUC) of 1 year, 3 years, and 5 years of survival were 0.813, 0.789, and 0.752, respectively. Furthermore, a prognostic nomogram including CRlncSig with clinicopathologic factors was built with favorable predictive power. In addition, GO and KEGG enrichment analysis suggested that CRlncSig was involved in many carcinogenesis and immune-related pathways. Additionally, we found that tumor microenvironment, immune infiltration, immune function, and drug response were significantly different between the high-risk and low-risk groups based on the risk model. These results highlight the value of cuproptosis-related lncRNAs on prognosis for HCC patients and provide insight into molecular and immune features underlying cuproptosis-related lncRNAs, which might play an important role in patient management and immunotherapy. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9538148/ /pubmed/36212138 http://dx.doi.org/10.3389/fgene.2022.972212 Text en Copyright © 2022 Zhu, Mao, Wang, Feng and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Zhu, Hongfei Mao, Feifei Wang, Kang Feng, Jinkai Cheng, Shuqun Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
title | Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
title_full | Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
title_fullStr | Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
title_full_unstemmed | Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
title_short | Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
title_sort | cuproptosis-related lncrnas predict the clinical outcome and immune characteristics of hepatocellular carcinoma |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538148/ https://www.ncbi.nlm.nih.gov/pubmed/36212138 http://dx.doi.org/10.3389/fgene.2022.972212 |
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