Cargando…

Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma

Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation of lipoylated mitochondrial proteins and the instability of Fe-S cluster proteins. However, the role of cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has n...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Hongfei, Mao, Feifei, Wang, Kang, Feng, Jinkai, Cheng, Shuqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538148/
https://www.ncbi.nlm.nih.gov/pubmed/36212138
http://dx.doi.org/10.3389/fgene.2022.972212
_version_ 1784803319302062080
author Zhu, Hongfei
Mao, Feifei
Wang, Kang
Feng, Jinkai
Cheng, Shuqun
author_facet Zhu, Hongfei
Mao, Feifei
Wang, Kang
Feng, Jinkai
Cheng, Shuqun
author_sort Zhu, Hongfei
collection PubMed
description Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation of lipoylated mitochondrial proteins and the instability of Fe-S cluster proteins. However, the role of cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has not been clearly elucidated. In this study, we identified and characterized cuproptosis-related lncRNAs in HCC. 343 HCC cases from The Cancer Genome Atlas (TCGA) with gene transcriptome data and clinical data were obtained for analysis after the screening. Univariate and multivariate Cox proportional hazards analyses were performed to establish a prognostic cuproptosis-related lncRNA signature (CRlncSig). We established a prognosis-related model consisting of nine cuproptosis-related lncRNAs: GSEC, AL158166.1, AC005479.2, AL365361.1, AC026412.3, AL031985.3, LINC00426, AC009974.2, AC245060.7, which was validated in the internal cohort. High-risk group stratified by the CRlncSig was significantly related to poor prognosis (p < 0.001). The area under the receiver operating characteristic curve (AUC) of 1 year, 3 years, and 5 years of survival were 0.813, 0.789, and 0.752, respectively. Furthermore, a prognostic nomogram including CRlncSig with clinicopathologic factors was built with favorable predictive power. In addition, GO and KEGG enrichment analysis suggested that CRlncSig was involved in many carcinogenesis and immune-related pathways. Additionally, we found that tumor microenvironment, immune infiltration, immune function, and drug response were significantly different between the high-risk and low-risk groups based on the risk model. These results highlight the value of cuproptosis-related lncRNAs on prognosis for HCC patients and provide insight into molecular and immune features underlying cuproptosis-related lncRNAs, which might play an important role in patient management and immunotherapy.
format Online
Article
Text
id pubmed-9538148
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95381482022-10-08 Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma Zhu, Hongfei Mao, Feifei Wang, Kang Feng, Jinkai Cheng, Shuqun Front Genet Genetics Cuproptosis, as a novel copper-dependent and non-apoptotic form of cell death, is induced by aggregation of lipoylated mitochondrial proteins and the instability of Fe-S cluster proteins. However, the role of cuproptosis-related long noncoding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has not been clearly elucidated. In this study, we identified and characterized cuproptosis-related lncRNAs in HCC. 343 HCC cases from The Cancer Genome Atlas (TCGA) with gene transcriptome data and clinical data were obtained for analysis after the screening. Univariate and multivariate Cox proportional hazards analyses were performed to establish a prognostic cuproptosis-related lncRNA signature (CRlncSig). We established a prognosis-related model consisting of nine cuproptosis-related lncRNAs: GSEC, AL158166.1, AC005479.2, AL365361.1, AC026412.3, AL031985.3, LINC00426, AC009974.2, AC245060.7, which was validated in the internal cohort. High-risk group stratified by the CRlncSig was significantly related to poor prognosis (p < 0.001). The area under the receiver operating characteristic curve (AUC) of 1 year, 3 years, and 5 years of survival were 0.813, 0.789, and 0.752, respectively. Furthermore, a prognostic nomogram including CRlncSig with clinicopathologic factors was built with favorable predictive power. In addition, GO and KEGG enrichment analysis suggested that CRlncSig was involved in many carcinogenesis and immune-related pathways. Additionally, we found that tumor microenvironment, immune infiltration, immune function, and drug response were significantly different between the high-risk and low-risk groups based on the risk model. These results highlight the value of cuproptosis-related lncRNAs on prognosis for HCC patients and provide insight into molecular and immune features underlying cuproptosis-related lncRNAs, which might play an important role in patient management and immunotherapy. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9538148/ /pubmed/36212138 http://dx.doi.org/10.3389/fgene.2022.972212 Text en Copyright © 2022 Zhu, Mao, Wang, Feng and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhu, Hongfei
Mao, Feifei
Wang, Kang
Feng, Jinkai
Cheng, Shuqun
Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
title Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
title_full Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
title_fullStr Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
title_full_unstemmed Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
title_short Cuproptosis-related lncRNAs predict the clinical outcome and immune characteristics of hepatocellular carcinoma
title_sort cuproptosis-related lncrnas predict the clinical outcome and immune characteristics of hepatocellular carcinoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538148/
https://www.ncbi.nlm.nih.gov/pubmed/36212138
http://dx.doi.org/10.3389/fgene.2022.972212
work_keys_str_mv AT zhuhongfei cuproptosisrelatedlncrnaspredicttheclinicaloutcomeandimmunecharacteristicsofhepatocellularcarcinoma
AT maofeifei cuproptosisrelatedlncrnaspredicttheclinicaloutcomeandimmunecharacteristicsofhepatocellularcarcinoma
AT wangkang cuproptosisrelatedlncrnaspredicttheclinicaloutcomeandimmunecharacteristicsofhepatocellularcarcinoma
AT fengjinkai cuproptosisrelatedlncrnaspredicttheclinicaloutcomeandimmunecharacteristicsofhepatocellularcarcinoma
AT chengshuqun cuproptosisrelatedlncrnaspredicttheclinicaloutcomeandimmunecharacteristicsofhepatocellularcarcinoma