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T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
Immune-mediated inflammatory diseases(IMIDs) are referred to as highly disabling chronic diseases affecting different organs and systems. Inappropriate or excessive immune responses with chronic inflammation are typical manifestations. Usually in patients with chronic infection and cancer, due to lo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538155/ https://www.ncbi.nlm.nih.gov/pubmed/36211414 http://dx.doi.org/10.3389/fimmu.2022.977394 |
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author | Gao, Zhanyan Feng, Yang Xu, Jinhua Liang, Jun |
author_facet | Gao, Zhanyan Feng, Yang Xu, Jinhua Liang, Jun |
author_sort | Gao, Zhanyan |
collection | PubMed |
description | Immune-mediated inflammatory diseases(IMIDs) are referred to as highly disabling chronic diseases affecting different organs and systems. Inappropriate or excessive immune responses with chronic inflammation are typical manifestations. Usually in patients with chronic infection and cancer, due to long-term exposure to persistent antigens and inflammation microenvironment, T-cells are continuously stimulated and gradually differentiate into an exhausted state. Exhausted T-cells gradually lose effector function and characteristics of memory T-cells. However, existing studies have found that exhausted T-cells are not only present in the infection and tumor environment, but also in autoimmunity, and are associated with better prognosis of IMIDs. This suggests new prospects for the application of this reversible process of T-cell exhaustion in the treatment of IMID. This review will focus on the research progress of T-cell exhaustion in several IMIDs and its potential application for diagnosis and treatment in IMIDs. |
format | Online Article Text |
id | pubmed-9538155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95381552022-10-08 T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy Gao, Zhanyan Feng, Yang Xu, Jinhua Liang, Jun Front Immunol Immunology Immune-mediated inflammatory diseases(IMIDs) are referred to as highly disabling chronic diseases affecting different organs and systems. Inappropriate or excessive immune responses with chronic inflammation are typical manifestations. Usually in patients with chronic infection and cancer, due to long-term exposure to persistent antigens and inflammation microenvironment, T-cells are continuously stimulated and gradually differentiate into an exhausted state. Exhausted T-cells gradually lose effector function and characteristics of memory T-cells. However, existing studies have found that exhausted T-cells are not only present in the infection and tumor environment, but also in autoimmunity, and are associated with better prognosis of IMIDs. This suggests new prospects for the application of this reversible process of T-cell exhaustion in the treatment of IMID. This review will focus on the research progress of T-cell exhaustion in several IMIDs and its potential application for diagnosis and treatment in IMIDs. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9538155/ /pubmed/36211414 http://dx.doi.org/10.3389/fimmu.2022.977394 Text en Copyright © 2022 Gao, Feng, Xu and Liang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gao, Zhanyan Feng, Yang Xu, Jinhua Liang, Jun T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy |
title | T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy |
title_full | T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy |
title_fullStr | T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy |
title_full_unstemmed | T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy |
title_short | T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy |
title_sort | t-cell exhaustion in immune-mediated inflammatory diseases: new implications for immunotherapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538155/ https://www.ncbi.nlm.nih.gov/pubmed/36211414 http://dx.doi.org/10.3389/fimmu.2022.977394 |
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