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T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy

Immune-mediated inflammatory diseases(IMIDs) are referred to as highly disabling chronic diseases affecting different organs and systems. Inappropriate or excessive immune responses with chronic inflammation are typical manifestations. Usually in patients with chronic infection and cancer, due to lo...

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Autores principales: Gao, Zhanyan, Feng, Yang, Xu, Jinhua, Liang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538155/
https://www.ncbi.nlm.nih.gov/pubmed/36211414
http://dx.doi.org/10.3389/fimmu.2022.977394
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author Gao, Zhanyan
Feng, Yang
Xu, Jinhua
Liang, Jun
author_facet Gao, Zhanyan
Feng, Yang
Xu, Jinhua
Liang, Jun
author_sort Gao, Zhanyan
collection PubMed
description Immune-mediated inflammatory diseases(IMIDs) are referred to as highly disabling chronic diseases affecting different organs and systems. Inappropriate or excessive immune responses with chronic inflammation are typical manifestations. Usually in patients with chronic infection and cancer, due to long-term exposure to persistent antigens and inflammation microenvironment, T-cells are continuously stimulated and gradually differentiate into an exhausted state. Exhausted T-cells gradually lose effector function and characteristics of memory T-cells. However, existing studies have found that exhausted T-cells are not only present in the infection and tumor environment, but also in autoimmunity, and are associated with better prognosis of IMIDs. This suggests new prospects for the application of this reversible process of T-cell exhaustion in the treatment of IMID. This review will focus on the research progress of T-cell exhaustion in several IMIDs and its potential application for diagnosis and treatment in IMIDs.
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spelling pubmed-95381552022-10-08 T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy Gao, Zhanyan Feng, Yang Xu, Jinhua Liang, Jun Front Immunol Immunology Immune-mediated inflammatory diseases(IMIDs) are referred to as highly disabling chronic diseases affecting different organs and systems. Inappropriate or excessive immune responses with chronic inflammation are typical manifestations. Usually in patients with chronic infection and cancer, due to long-term exposure to persistent antigens and inflammation microenvironment, T-cells are continuously stimulated and gradually differentiate into an exhausted state. Exhausted T-cells gradually lose effector function and characteristics of memory T-cells. However, existing studies have found that exhausted T-cells are not only present in the infection and tumor environment, but also in autoimmunity, and are associated with better prognosis of IMIDs. This suggests new prospects for the application of this reversible process of T-cell exhaustion in the treatment of IMID. This review will focus on the research progress of T-cell exhaustion in several IMIDs and its potential application for diagnosis and treatment in IMIDs. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9538155/ /pubmed/36211414 http://dx.doi.org/10.3389/fimmu.2022.977394 Text en Copyright © 2022 Gao, Feng, Xu and Liang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gao, Zhanyan
Feng, Yang
Xu, Jinhua
Liang, Jun
T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
title T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
title_full T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
title_fullStr T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
title_full_unstemmed T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
title_short T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy
title_sort t-cell exhaustion in immune-mediated inflammatory diseases: new implications for immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538155/
https://www.ncbi.nlm.nih.gov/pubmed/36211414
http://dx.doi.org/10.3389/fimmu.2022.977394
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