The retina of the lab rat: focus on retinal ganglion cells and photoreceptors

Albino and pigmented rat strains are widely used in models to study retinal degeneration and to test new therapies. Here, we have summarized the main topographical and functional characteristics of the rat retina focussing on photoreceptors and retinal ganglion cells (RGCs), the beginning and end of...

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Detalles Bibliográficos
Autores principales: Galindo-Romero, Caridad, Norte-Muñoz, María, Gallego-Ortega, Alejandro, Rodríguez-Ramírez, Kristy T., Lucas-Ruiz, Fernando, González-Riquelme, María Josefa, Vidal-Sanz, Manuel, Agudo-Barriuso, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538360/
https://www.ncbi.nlm.nih.gov/pubmed/36213609
http://dx.doi.org/10.3389/fnana.2022.994890
Descripción
Sumario:Albino and pigmented rat strains are widely used in models to study retinal degeneration and to test new therapies. Here, we have summarized the main topographical and functional characteristics of the rat retina focussing on photoreceptors and retinal ganglion cells (RGCs), the beginning and end of the retinal circuitry, respectively. These neurons are very sensitive to injury and disease, and thus knowing their normal number, topography, and function is essential to accurately investigate on neuronal survival and protection.

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