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Thyroid and renal cancers: A bidirectional association

There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several...

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Autores principales: Bellini, Maria Irene, Lori, Eleonora, Forte, Flavio, Lauro, Augusto, Tripodi, Domenico, Amabile, Maria Ida, Cantisani, Vito, Varanese, Marzia, Ferent, Iulia Catalina, Baldini, Enke, Ulisse, Salvatore, D’Andrea, Vito, Pironi, Daniele, Sorrenti, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538481/
https://www.ncbi.nlm.nih.gov/pubmed/36212468
http://dx.doi.org/10.3389/fonc.2022.951976
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author Bellini, Maria Irene
Lori, Eleonora
Forte, Flavio
Lauro, Augusto
Tripodi, Domenico
Amabile, Maria Ida
Cantisani, Vito
Varanese, Marzia
Ferent, Iulia Catalina
Baldini, Enke
Ulisse, Salvatore
D’Andrea, Vito
Pironi, Daniele
Sorrenti, Salvatore
author_facet Bellini, Maria Irene
Lori, Eleonora
Forte, Flavio
Lauro, Augusto
Tripodi, Domenico
Amabile, Maria Ida
Cantisani, Vito
Varanese, Marzia
Ferent, Iulia Catalina
Baldini, Enke
Ulisse, Salvatore
D’Andrea, Vito
Pironi, Daniele
Sorrenti, Salvatore
author_sort Bellini, Maria Irene
collection PubMed
description There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several malignancies, such as breast cancer, prostate cancer, colorectal cancer, and other, with an increased risk of kidney disease, public health alert for these conditions is warranted. A systematic review of the current evidence on the bidirectional relationship between thyroid and renal cancers was conducted including 18 studies, highlighting patient’s characteristics, histology, time for secondary malignancy to develop from the first diagnosis, treatment, and follow-up. A total of 776 patients were identified; median age was 64 years (range: 7–76 years). Obesity and family history were identified as the most common risk factors, and genetic susceptibility was suggested with a potential strong association with Cowden syndrome. Controversy on chemo and radiotherapy effects was found, as not all patients were previously exposed to these treatments. Men were more likely to develop kidney cancer after a primary thyroid malignancy, with 423/776 (54%) experiencing renal disease secondarily. Median time after the first malignancy was 5.2 years (range: 0–20 years). With the advancement of current oncological therapy, the prognosis for thyroid cancer patients has improved, although there has been a corresponding rise in the incidence of multiple secondary malignancy within the same population, particularly concerning the kidney. Surgery can achieve disease-free survival, if surveillance follow-up allows for an early localized form, where radical treatment is recommended.
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spelling pubmed-95384812022-10-08 Thyroid and renal cancers: A bidirectional association Bellini, Maria Irene Lori, Eleonora Forte, Flavio Lauro, Augusto Tripodi, Domenico Amabile, Maria Ida Cantisani, Vito Varanese, Marzia Ferent, Iulia Catalina Baldini, Enke Ulisse, Salvatore D’Andrea, Vito Pironi, Daniele Sorrenti, Salvatore Front Oncol Oncology There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several malignancies, such as breast cancer, prostate cancer, colorectal cancer, and other, with an increased risk of kidney disease, public health alert for these conditions is warranted. A systematic review of the current evidence on the bidirectional relationship between thyroid and renal cancers was conducted including 18 studies, highlighting patient’s characteristics, histology, time for secondary malignancy to develop from the first diagnosis, treatment, and follow-up. A total of 776 patients were identified; median age was 64 years (range: 7–76 years). Obesity and family history were identified as the most common risk factors, and genetic susceptibility was suggested with a potential strong association with Cowden syndrome. Controversy on chemo and radiotherapy effects was found, as not all patients were previously exposed to these treatments. Men were more likely to develop kidney cancer after a primary thyroid malignancy, with 423/776 (54%) experiencing renal disease secondarily. Median time after the first malignancy was 5.2 years (range: 0–20 years). With the advancement of current oncological therapy, the prognosis for thyroid cancer patients has improved, although there has been a corresponding rise in the incidence of multiple secondary malignancy within the same population, particularly concerning the kidney. Surgery can achieve disease-free survival, if surveillance follow-up allows for an early localized form, where radical treatment is recommended. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9538481/ /pubmed/36212468 http://dx.doi.org/10.3389/fonc.2022.951976 Text en Copyright © 2022 Bellini, Lori, Forte, Lauro, Tripodi, Amabile, Cantisani, Varanese, Ferent, Baldini, Ulisse, D’Andrea, Pironi and Sorrenti https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bellini, Maria Irene
Lori, Eleonora
Forte, Flavio
Lauro, Augusto
Tripodi, Domenico
Amabile, Maria Ida
Cantisani, Vito
Varanese, Marzia
Ferent, Iulia Catalina
Baldini, Enke
Ulisse, Salvatore
D’Andrea, Vito
Pironi, Daniele
Sorrenti, Salvatore
Thyroid and renal cancers: A bidirectional association
title Thyroid and renal cancers: A bidirectional association
title_full Thyroid and renal cancers: A bidirectional association
title_fullStr Thyroid and renal cancers: A bidirectional association
title_full_unstemmed Thyroid and renal cancers: A bidirectional association
title_short Thyroid and renal cancers: A bidirectional association
title_sort thyroid and renal cancers: a bidirectional association
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538481/
https://www.ncbi.nlm.nih.gov/pubmed/36212468
http://dx.doi.org/10.3389/fonc.2022.951976
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