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Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients
BACKGROUND: The clinical, neuropsychological, and socioeconomic factors affecting Parkinson's disease (PD) during COVID‐19 pandemic across different populations have not been systematically studied. To address this, we conducted a meta‐analysis of factors that impact the well‐being of PD patien...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538738/ https://www.ncbi.nlm.nih.gov/pubmed/36065787 http://dx.doi.org/10.1002/acn3.51616 |
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author | Mai, Aaron Shengting Yong, Jung Hahn Tan, Brendan Jen‐Wei Xiao, Bin Tan, Eng‐King |
author_facet | Mai, Aaron Shengting Yong, Jung Hahn Tan, Brendan Jen‐Wei Xiao, Bin Tan, Eng‐King |
author_sort | Mai, Aaron Shengting |
collection | PubMed |
description | BACKGROUND: The clinical, neuropsychological, and socioeconomic factors affecting Parkinson's disease (PD) during COVID‐19 pandemic across different populations have not been systematically studied. To address this, we conducted a meta‐analysis of factors that impact the well‐being of PD patients during the pandemic. METHODS: Medline and Embase were searched for articles published between 2020 and 2022. We conducted random‐effects pooling of estimates and meta‐regression. RESULTS: Twenty‐seven studies involving 13,878 patients from America, Europe, Asia, and Africa were included. There is a high prevalence of decreased physical activity and exercise, and worsening motor and neuropsychiatric symptoms (17–56%). Patients in lower‐income countries more frequently reported worsening anxiety (adjusted OR [aOR] 8.94, 95% confidence interval [CI] 1.62–49.28, p = 0.012), sleep (aOR 5.16, 95% CI 1.15–23.17, p = 0.032), and PD symptoms (aOR 3.57, 95% CI 0.96–13.34, p = 0.058). Lockdown was associated with decreased exercise levels (aOR 0.13, 95% CI 0.02–0.78, p = 0.025) and worsening mood (aOR 0.48, 95% CI 0.24–0.95, p = 0.035). Younger age correlated with decreased physical activity (β −0.30, 95% CI −0.53 to −0.07, p = 0.012), exercise (β −0.11, 95% CI −0.15 to −0.07, p < 0.001), worsening PD symptoms (β −0.08, 95% CI −0.15 to −0.01, p = 0.018), and sleep (β −0.14, 95% CI −0.27 to 0, p = 0.044). Female PD patients reported a greater decrease in physical activity (β 11.94, 95% CI 2.17–21.71, p = 0.017) and worse sleep (β 10.76, 95% CI 2.81–18.70, p = 0.008). CONCLUSION: This large meta‐analysis of PD patients in diverse populations identified a high prevalence of physical and mental worsening during the COVID‐19 pandemic, with patients in lower‐income countries being exceptionally vulnerable. |
format | Online Article Text |
id | pubmed-9538738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95387382022-10-11 Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients Mai, Aaron Shengting Yong, Jung Hahn Tan, Brendan Jen‐Wei Xiao, Bin Tan, Eng‐King Ann Clin Transl Neurol Research Articles BACKGROUND: The clinical, neuropsychological, and socioeconomic factors affecting Parkinson's disease (PD) during COVID‐19 pandemic across different populations have not been systematically studied. To address this, we conducted a meta‐analysis of factors that impact the well‐being of PD patients during the pandemic. METHODS: Medline and Embase were searched for articles published between 2020 and 2022. We conducted random‐effects pooling of estimates and meta‐regression. RESULTS: Twenty‐seven studies involving 13,878 patients from America, Europe, Asia, and Africa were included. There is a high prevalence of decreased physical activity and exercise, and worsening motor and neuropsychiatric symptoms (17–56%). Patients in lower‐income countries more frequently reported worsening anxiety (adjusted OR [aOR] 8.94, 95% confidence interval [CI] 1.62–49.28, p = 0.012), sleep (aOR 5.16, 95% CI 1.15–23.17, p = 0.032), and PD symptoms (aOR 3.57, 95% CI 0.96–13.34, p = 0.058). Lockdown was associated with decreased exercise levels (aOR 0.13, 95% CI 0.02–0.78, p = 0.025) and worsening mood (aOR 0.48, 95% CI 0.24–0.95, p = 0.035). Younger age correlated with decreased physical activity (β −0.30, 95% CI −0.53 to −0.07, p = 0.012), exercise (β −0.11, 95% CI −0.15 to −0.07, p < 0.001), worsening PD symptoms (β −0.08, 95% CI −0.15 to −0.01, p = 0.018), and sleep (β −0.14, 95% CI −0.27 to 0, p = 0.044). Female PD patients reported a greater decrease in physical activity (β 11.94, 95% CI 2.17–21.71, p = 0.017) and worse sleep (β 10.76, 95% CI 2.81–18.70, p = 0.008). CONCLUSION: This large meta‐analysis of PD patients in diverse populations identified a high prevalence of physical and mental worsening during the COVID‐19 pandemic, with patients in lower‐income countries being exceptionally vulnerable. John Wiley and Sons Inc. 2022-09-06 /pmc/articles/PMC9538738/ /pubmed/36065787 http://dx.doi.org/10.1002/acn3.51616 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Mai, Aaron Shengting Yong, Jung Hahn Tan, Brendan Jen‐Wei Xiao, Bin Tan, Eng‐King Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients |
title | Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients |
title_full | Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients |
title_fullStr | Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients |
title_full_unstemmed | Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients |
title_short | Impact of COVID‐19 pandemic on patients with Parkinson's disease: A meta‐analysis of 13,878 patients |
title_sort | impact of covid‐19 pandemic on patients with parkinson's disease: a meta‐analysis of 13,878 patients |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538738/ https://www.ncbi.nlm.nih.gov/pubmed/36065787 http://dx.doi.org/10.1002/acn3.51616 |
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