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mRNA nanomedicine: Design and recent applications
The rational design and application of mRNA‐based medicine have recently yielded some key successes in the clinical management of human diseases. mRNA technology allows for the facile and direct production of proteins in vivo, thus circumventing the need for lengthy drug development cycles and compl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539018/ https://www.ncbi.nlm.nih.gov/pubmed/36249890 http://dx.doi.org/10.1002/EXP.20210217 |
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author | Kubiatowicz, Luke J. Mohapatra, Animesh Krishnan, Nishta Fang, Ronnie H. Zhang, Liangfang |
author_facet | Kubiatowicz, Luke J. Mohapatra, Animesh Krishnan, Nishta Fang, Ronnie H. Zhang, Liangfang |
author_sort | Kubiatowicz, Luke J. |
collection | PubMed |
description | The rational design and application of mRNA‐based medicine have recently yielded some key successes in the clinical management of human diseases. mRNA technology allows for the facile and direct production of proteins in vivo, thus circumventing the need for lengthy drug development cycles and complex production workflows. As such, mRNA formulations can significantly improve upon the biological therapies that have become commonplace in modern medicine. Despite its many advantages, mRNA is inherently fragile and has specific delivery requirements. Leveraging the engineering flexibility of nanobiotechnology, mRNA payloads can be incorporated into nanoformulations such that they do not invoke unwanted immune responses, are targeted to tissues of interest, and can be delivered to the cytosol, resulting in improved safety while enhancing bioactivity. With the rapidly evolving landscape of nanomedicine, novel technologies that are under development have the potential to further improve the clinical utility of mRNA medicine. This review covers the design principles relevant to engineering mRNA‐based nanomedicine platforms. It also details the current research on mRNA nanoformulations for addressing viral infections, cancers, and genetic diseases. Given the trends in the field, future mRNA‐based nanomedicines have the potential to change how many types of diseases are managed in the clinic. |
format | Online Article Text |
id | pubmed-9539018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95390182022-10-11 mRNA nanomedicine: Design and recent applications Kubiatowicz, Luke J. Mohapatra, Animesh Krishnan, Nishta Fang, Ronnie H. Zhang, Liangfang Exploration (Beijing) Reviews The rational design and application of mRNA‐based medicine have recently yielded some key successes in the clinical management of human diseases. mRNA technology allows for the facile and direct production of proteins in vivo, thus circumventing the need for lengthy drug development cycles and complex production workflows. As such, mRNA formulations can significantly improve upon the biological therapies that have become commonplace in modern medicine. Despite its many advantages, mRNA is inherently fragile and has specific delivery requirements. Leveraging the engineering flexibility of nanobiotechnology, mRNA payloads can be incorporated into nanoformulations such that they do not invoke unwanted immune responses, are targeted to tissues of interest, and can be delivered to the cytosol, resulting in improved safety while enhancing bioactivity. With the rapidly evolving landscape of nanomedicine, novel technologies that are under development have the potential to further improve the clinical utility of mRNA medicine. This review covers the design principles relevant to engineering mRNA‐based nanomedicine platforms. It also details the current research on mRNA nanoformulations for addressing viral infections, cancers, and genetic diseases. Given the trends in the field, future mRNA‐based nanomedicines have the potential to change how many types of diseases are managed in the clinic. John Wiley and Sons Inc. 2022-09-19 /pmc/articles/PMC9539018/ /pubmed/36249890 http://dx.doi.org/10.1002/EXP.20210217 Text en © 2022 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Kubiatowicz, Luke J. Mohapatra, Animesh Krishnan, Nishta Fang, Ronnie H. Zhang, Liangfang mRNA nanomedicine: Design and recent applications |
title | mRNA nanomedicine: Design and recent applications |
title_full | mRNA nanomedicine: Design and recent applications |
title_fullStr | mRNA nanomedicine: Design and recent applications |
title_full_unstemmed | mRNA nanomedicine: Design and recent applications |
title_short | mRNA nanomedicine: Design and recent applications |
title_sort | mrna nanomedicine: design and recent applications |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539018/ https://www.ncbi.nlm.nih.gov/pubmed/36249890 http://dx.doi.org/10.1002/EXP.20210217 |
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