PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance

PIWI-interacting RNAs (piRNAs) are a less-studied class of small non-coding RNAs approximately 24–31 nucleotides in length. They express in germline and somatic cells and form complexes with PIWI proteins to exert regulatory effects. New studies show that piRNAs are aberrantly expressed in various c...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Jie, Xie, Mei, Ma, Xidong, Song, Jialin, Wang, Yuanyong, Xue, Xinying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539321/
https://www.ncbi.nlm.nih.gov/pubmed/36212439
http://dx.doi.org/10.3389/fonc.2022.965684
_version_ 1784803465451536384
author Yao, Jie
Xie, Mei
Ma, Xidong
Song, Jialin
Wang, Yuanyong
Xue, Xinying
author_facet Yao, Jie
Xie, Mei
Ma, Xidong
Song, Jialin
Wang, Yuanyong
Xue, Xinying
author_sort Yao, Jie
collection PubMed
description PIWI-interacting RNAs (piRNAs) are a less-studied class of small non-coding RNAs approximately 24–31 nucleotides in length. They express in germline and somatic cells and form complexes with PIWI proteins to exert regulatory effects. New studies show that piRNAs are aberrantly expressed in various cancers. In this review, we focus on those piRNAs that are associated with cancer hallmarks such as proliferation, invasion, and chemoresistance and discuss their potential as biomarkers for cancer diagnosis and prognosis.
format Online
Article
Text
id pubmed-9539321
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95393212022-10-08 PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance Yao, Jie Xie, Mei Ma, Xidong Song, Jialin Wang, Yuanyong Xue, Xinying Front Oncol Oncology PIWI-interacting RNAs (piRNAs) are a less-studied class of small non-coding RNAs approximately 24–31 nucleotides in length. They express in germline and somatic cells and form complexes with PIWI proteins to exert regulatory effects. New studies show that piRNAs are aberrantly expressed in various cancers. In this review, we focus on those piRNAs that are associated with cancer hallmarks such as proliferation, invasion, and chemoresistance and discuss their potential as biomarkers for cancer diagnosis and prognosis. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9539321/ /pubmed/36212439 http://dx.doi.org/10.3389/fonc.2022.965684 Text en Copyright © 2022 Yao, Xie, Ma, Song, Wang and Xue https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yao, Jie
Xie, Mei
Ma, Xidong
Song, Jialin
Wang, Yuanyong
Xue, Xinying
PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance
title PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance
title_full PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance
title_fullStr PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance
title_full_unstemmed PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance
title_short PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance
title_sort piwi-interacting rnas in cancer: biogenesis, function, and clinical significance
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539321/
https://www.ncbi.nlm.nih.gov/pubmed/36212439
http://dx.doi.org/10.3389/fonc.2022.965684
work_keys_str_mv AT yaojie piwiinteractingrnasincancerbiogenesisfunctionandclinicalsignificance
AT xiemei piwiinteractingrnasincancerbiogenesisfunctionandclinicalsignificance
AT maxidong piwiinteractingrnasincancerbiogenesisfunctionandclinicalsignificance
AT songjialin piwiinteractingrnasincancerbiogenesisfunctionandclinicalsignificance
AT wangyuanyong piwiinteractingrnasincancerbiogenesisfunctionandclinicalsignificance
AT xuexinying piwiinteractingrnasincancerbiogenesisfunctionandclinicalsignificance

Ejemplares similares