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Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation
OBJECTIVE: Increasing life expectancy and aging of the population is accompanied by a steady increase in the number of elderly patients with chronic cerebral ischemia and age-related cognitive impairment associated with cerebral hypoperfusion and microangiopathy. The aim of this study was to identif...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539408/ https://www.ncbi.nlm.nih.gov/pubmed/36211284 http://dx.doi.org/10.3389/fsurg.2022.1026079 |
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author | Zhao, Shu Sufianova, Galina Shapkin, Andrey Mashkin, Andrey Meshcheryakova, Svetlana Han, Dayong |
author_facet | Zhao, Shu Sufianova, Galina Shapkin, Andrey Mashkin, Andrey Meshcheryakova, Svetlana Han, Dayong |
author_sort | Zhao, Shu |
collection | PubMed |
description | OBJECTIVE: Increasing life expectancy and aging of the population is accompanied by a steady increase in the number of elderly patients with chronic cerebral ischemia and age-related cognitive impairment associated with cerebral hypoperfusion and microangiopathy. The aim of this study was to identify long-term changes in cerebral blood flow (CBF) in patients with chronic cerebral ischemia at the epidural electrical stimulation of the spinal cord (SCS). MATERIALS AND METHODS: Changes in cerebral blood flow were studied according to CT perfusion in 59 patients (aged 55–78 years) with vertebrogenic pain syndromes and chronic cerebral ischemia during epidural electrical stimulation of the spinal cord at the cervical (C3–C5) and lower thoracic (Th9–Th10) levels. RESULTS: In all patients, on the 5th day of trial SCS, an increase in cerebral blood flow by from 58.6 ± 1.13 ml/100 ml/min to 64.8 ± 1.21 ml/100 ml/min (p < 0.01) with stimulation at the Th9-Th10 level and from 58.8 ± 1.12 ml/100 ml/min to 68.2 ± 1.42 ml/100 ml/min (p < 0, 01) with stimulation at the C3-C5 level. These changes in brain perfusion were preserved during the follow-up examination 1 year after the implantation of chronic SCS system. The greatest increase in CBF was registered in the frontotemporal regions, subcortical structures and white matter of the brain. Changes in cerebral perfusion did not correlate with the degree of reduction in the severity of the accompanying pain syndrome. The change in CBF in the control group (32 patients) in all periods was not statistically significant. CONCLUSION: Our results show that SCS is accompanied by a persistent improvement in brain perfusion, which may be potentially useful for developing methods for reducing age-related vascular disorders in the elderly. |
format | Online Article Text |
id | pubmed-9539408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95394082022-10-08 Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation Zhao, Shu Sufianova, Galina Shapkin, Andrey Mashkin, Andrey Meshcheryakova, Svetlana Han, Dayong Front Surg Surgery OBJECTIVE: Increasing life expectancy and aging of the population is accompanied by a steady increase in the number of elderly patients with chronic cerebral ischemia and age-related cognitive impairment associated with cerebral hypoperfusion and microangiopathy. The aim of this study was to identify long-term changes in cerebral blood flow (CBF) in patients with chronic cerebral ischemia at the epidural electrical stimulation of the spinal cord (SCS). MATERIALS AND METHODS: Changes in cerebral blood flow were studied according to CT perfusion in 59 patients (aged 55–78 years) with vertebrogenic pain syndromes and chronic cerebral ischemia during epidural electrical stimulation of the spinal cord at the cervical (C3–C5) and lower thoracic (Th9–Th10) levels. RESULTS: In all patients, on the 5th day of trial SCS, an increase in cerebral blood flow by from 58.6 ± 1.13 ml/100 ml/min to 64.8 ± 1.21 ml/100 ml/min (p < 0.01) with stimulation at the Th9-Th10 level and from 58.8 ± 1.12 ml/100 ml/min to 68.2 ± 1.42 ml/100 ml/min (p < 0, 01) with stimulation at the C3-C5 level. These changes in brain perfusion were preserved during the follow-up examination 1 year after the implantation of chronic SCS system. The greatest increase in CBF was registered in the frontotemporal regions, subcortical structures and white matter of the brain. Changes in cerebral perfusion did not correlate with the degree of reduction in the severity of the accompanying pain syndrome. The change in CBF in the control group (32 patients) in all periods was not statistically significant. CONCLUSION: Our results show that SCS is accompanied by a persistent improvement in brain perfusion, which may be potentially useful for developing methods for reducing age-related vascular disorders in the elderly. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9539408/ /pubmed/36211284 http://dx.doi.org/10.3389/fsurg.2022.1026079 Text en © Zhao, Sufianova, Shapkin, Mashkin, Meshcheryakova and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Zhao, Shu Sufianova, Galina Shapkin, Andrey Mashkin, Andrey Meshcheryakova, Svetlana Han, Dayong Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
title | Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
title_full | Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
title_fullStr | Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
title_full_unstemmed | Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
title_short | Improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
title_sort | improvement of brain perfusion in patients with chronic brain ischemia at epidural spinal cord electrical stimulation |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539408/ https://www.ncbi.nlm.nih.gov/pubmed/36211284 http://dx.doi.org/10.3389/fsurg.2022.1026079 |
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