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Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells

The GPR15 receptor is a G protein‐coupled receptor (GPCR), which is activated by an endogenous peptide GPR15L(25–81) and a C‐terminal peptide fragment GPR15L(71–81). GPR15 signals through the G(i/o) pathway to decrease intracellular cyclic adenosine 3′,5′‐monophosphate (cAMP). However, the activatio...

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Detalles Bibliográficos
Autores principales: Deng, Yufang, Moo, Ee Von, Almería, Claudia Victoria Pérez, Gentry, Patrick R., Vedel, Line, Mathiesen, Jesper M., Bräuner‐Osborne, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539578/
https://www.ncbi.nlm.nih.gov/pubmed/35510660
http://dx.doi.org/10.1111/bcpt.13738