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The beneficial metabolic actions of prolactin
The role of prolactin (PRL) favoring metabolic homeostasis is supported by multiple preclinical and clinical studies. PRL levels are key to explaining the direction of its actions. In contrast with the negative outcomes associated with very high (>100 μg/L) and very low (<7 μg/L) PRL levels, m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539817/ https://www.ncbi.nlm.nih.gov/pubmed/36213259 http://dx.doi.org/10.3389/fendo.2022.1001703 |
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author | Macotela, Yazmín Ruiz-Herrera, Xarubet Vázquez-Carrillo, Dina I. Ramírez-Hernandez, Gabriela Martínez de la Escalera, Gonzalo Clapp, Carmen |
author_facet | Macotela, Yazmín Ruiz-Herrera, Xarubet Vázquez-Carrillo, Dina I. Ramírez-Hernandez, Gabriela Martínez de la Escalera, Gonzalo Clapp, Carmen |
author_sort | Macotela, Yazmín |
collection | PubMed |
description | The role of prolactin (PRL) favoring metabolic homeostasis is supported by multiple preclinical and clinical studies. PRL levels are key to explaining the direction of its actions. In contrast with the negative outcomes associated with very high (>100 μg/L) and very low (<7 μg/L) PRL levels, moderately high PRL levels, both within but also above the classically considered physiological range are beneficial for metabolism and have been defined as HomeoFIT-PRL. In animal models, HomeoFIT-PRL levels counteract insulin resistance, glucose intolerance, adipose tissue hypertrophy and fatty liver; and in humans associate with reduced prevalence of insulin resistance, fatty liver, glucose intolerance, metabolic syndrome, reduced adipocyte hypertrophy, and protection from type 2 diabetes development. The beneficial actions of PRL can be explained by its positive effects on main metabolic organs including the pancreas, liver, adipose tissue, and hypothalamus. Here, we briefly review work supporting PRL as a promoter of metabolic homeostasis in rodents and humans, the PRL levels associated with metabolic protection, and the proposed mechanisms involved. Finally, we discuss the possibility of using drugs elevating PRL for the treatment of metabolic diseases. |
format | Online Article Text |
id | pubmed-9539817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95398172022-10-08 The beneficial metabolic actions of prolactin Macotela, Yazmín Ruiz-Herrera, Xarubet Vázquez-Carrillo, Dina I. Ramírez-Hernandez, Gabriela Martínez de la Escalera, Gonzalo Clapp, Carmen Front Endocrinol (Lausanne) Endocrinology The role of prolactin (PRL) favoring metabolic homeostasis is supported by multiple preclinical and clinical studies. PRL levels are key to explaining the direction of its actions. In contrast with the negative outcomes associated with very high (>100 μg/L) and very low (<7 μg/L) PRL levels, moderately high PRL levels, both within but also above the classically considered physiological range are beneficial for metabolism and have been defined as HomeoFIT-PRL. In animal models, HomeoFIT-PRL levels counteract insulin resistance, glucose intolerance, adipose tissue hypertrophy and fatty liver; and in humans associate with reduced prevalence of insulin resistance, fatty liver, glucose intolerance, metabolic syndrome, reduced adipocyte hypertrophy, and protection from type 2 diabetes development. The beneficial actions of PRL can be explained by its positive effects on main metabolic organs including the pancreas, liver, adipose tissue, and hypothalamus. Here, we briefly review work supporting PRL as a promoter of metabolic homeostasis in rodents and humans, the PRL levels associated with metabolic protection, and the proposed mechanisms involved. Finally, we discuss the possibility of using drugs elevating PRL for the treatment of metabolic diseases. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9539817/ /pubmed/36213259 http://dx.doi.org/10.3389/fendo.2022.1001703 Text en Copyright © 2022 Macotela, Ruiz-Herrera, Vázquez-Carrillo, Ramírez-Hernandez, Martínez de la Escalera and Clapp https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Macotela, Yazmín Ruiz-Herrera, Xarubet Vázquez-Carrillo, Dina I. Ramírez-Hernandez, Gabriela Martínez de la Escalera, Gonzalo Clapp, Carmen The beneficial metabolic actions of prolactin |
title | The beneficial metabolic actions of prolactin |
title_full | The beneficial metabolic actions of prolactin |
title_fullStr | The beneficial metabolic actions of prolactin |
title_full_unstemmed | The beneficial metabolic actions of prolactin |
title_short | The beneficial metabolic actions of prolactin |
title_sort | beneficial metabolic actions of prolactin |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539817/ https://www.ncbi.nlm.nih.gov/pubmed/36213259 http://dx.doi.org/10.3389/fendo.2022.1001703 |
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