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Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation
Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast. In Germany, hantavi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539979/ https://www.ncbi.nlm.nih.gov/pubmed/35312223 http://dx.doi.org/10.1111/zph.12940 |
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author | Princk, Christina Drewes, Stephan Meyer‐Schlinkmann, Kristin M. Saathoff, Marion Binder, Florian Freise, Jona Tenner, Beate Weiss, Sabrina Hofmann, Jörg Esser, Jutta Runge, Martin Jacob, Jens Ulrich, Rainer G. Dreesman, Johannes |
author_facet | Princk, Christina Drewes, Stephan Meyer‐Schlinkmann, Kristin M. Saathoff, Marion Binder, Florian Freise, Jona Tenner, Beate Weiss, Sabrina Hofmann, Jörg Esser, Jutta Runge, Martin Jacob, Jens Ulrich, Rainer G. Dreesman, Johannes |
author_sort | Princk, Christina |
collection | PubMed |
description | Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast. In Germany, hantavirus epidemic years are observed in 2‐ to 5‐year intervals. Many of the human infections are recorded in summer and early autumn, coinciding with peaks in bank vole populations. Here, we describe a molecular epidemiological investigation in a small company with eight employees of whom five contracted hantavirus infections in late 2017. Standardized interviews with employees were conducted to assess the circumstances under which the disease cluster occurred, how the employees were exposed and which counteractive measures were taken. Initially, two employees were admitted to hospital and serologically diagnosed with hantavirus infection. Subsequently, further investigations were conducted. By means of a self‐administered questionnaire, three additional symptomatic cases could be identified. The hospital patients' sera were investigated and revealed in one patient a partial PUUV L segment sequence, which was identical to PUUV sequences from several bank voles collected in close proximity to company buildings. This investigation highlights the importance of a One Health approach that combines efforts from human and veterinary medicine, ecology and public health to reveal the origin of hantavirus disease clusters. |
format | Online Article Text |
id | pubmed-9539979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95399792022-10-14 Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation Princk, Christina Drewes, Stephan Meyer‐Schlinkmann, Kristin M. Saathoff, Marion Binder, Florian Freise, Jona Tenner, Beate Weiss, Sabrina Hofmann, Jörg Esser, Jutta Runge, Martin Jacob, Jens Ulrich, Rainer G. Dreesman, Johannes Zoonoses Public Health Short Communications Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast. In Germany, hantavirus epidemic years are observed in 2‐ to 5‐year intervals. Many of the human infections are recorded in summer and early autumn, coinciding with peaks in bank vole populations. Here, we describe a molecular epidemiological investigation in a small company with eight employees of whom five contracted hantavirus infections in late 2017. Standardized interviews with employees were conducted to assess the circumstances under which the disease cluster occurred, how the employees were exposed and which counteractive measures were taken. Initially, two employees were admitted to hospital and serologically diagnosed with hantavirus infection. Subsequently, further investigations were conducted. By means of a self‐administered questionnaire, three additional symptomatic cases could be identified. The hospital patients' sera were investigated and revealed in one patient a partial PUUV L segment sequence, which was identical to PUUV sequences from several bank voles collected in close proximity to company buildings. This investigation highlights the importance of a One Health approach that combines efforts from human and veterinary medicine, ecology and public health to reveal the origin of hantavirus disease clusters. John Wiley and Sons Inc. 2022-03-21 2022-08 /pmc/articles/PMC9539979/ /pubmed/35312223 http://dx.doi.org/10.1111/zph.12940 Text en © 2022 The Authors. Zoonoses and Public Health published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Short Communications Princk, Christina Drewes, Stephan Meyer‐Schlinkmann, Kristin M. Saathoff, Marion Binder, Florian Freise, Jona Tenner, Beate Weiss, Sabrina Hofmann, Jörg Esser, Jutta Runge, Martin Jacob, Jens Ulrich, Rainer G. Dreesman, Johannes Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation |
title | Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation |
title_full | Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation |
title_fullStr | Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation |
title_full_unstemmed | Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation |
title_short | Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation |
title_sort | cluster of human puumala orthohantavirus infections due to indoor exposure?—an interdisciplinary outbreak investigation |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539979/ https://www.ncbi.nlm.nih.gov/pubmed/35312223 http://dx.doi.org/10.1111/zph.12940 |
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