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The complement system in pediatric acute kidney injury
The complement cascade is an important part of the innate immune system. In addition to helping the body to eliminate pathogens, however, complement activation also contributes to the pathogenesis of a wide range of kidney diseases. Recent work has revealed that uncontrolled complement activation is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540254/ https://www.ncbi.nlm.nih.gov/pubmed/36203104 http://dx.doi.org/10.1007/s00467-022-05755-3 |
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author | Stenson, Erin K. Kendrick, Jessica Dixon, Bradley Thurman, Joshua M. |
author_facet | Stenson, Erin K. Kendrick, Jessica Dixon, Bradley Thurman, Joshua M. |
author_sort | Stenson, Erin K. |
collection | PubMed |
description | The complement cascade is an important part of the innate immune system. In addition to helping the body to eliminate pathogens, however, complement activation also contributes to the pathogenesis of a wide range of kidney diseases. Recent work has revealed that uncontrolled complement activation is the key driver of several rare kidney diseases in children, including atypical hemolytic uremic syndrome and C3 glomerulopathy. In addition, a growing body of literature has implicated complement in the pathogenesis of more common kidney diseases, including acute kidney injury (AKI). Complement-targeted therapeutics are in use for a variety of diseases, and an increasing number of therapeutic agents are under development. With the implication of complement in the pathogenesis of AKI, complement-targeted therapeutics could be trialed to prevent or treat this condition. In this review, we discuss the evidence that the complement system is activated in pediatric patients with AKI, and we review the role of complement proteins as biomarkers and therapeutic targets in patients with AKI. |
format | Online Article Text |
id | pubmed-9540254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-95402542022-10-11 The complement system in pediatric acute kidney injury Stenson, Erin K. Kendrick, Jessica Dixon, Bradley Thurman, Joshua M. Pediatr Nephrol Review The complement cascade is an important part of the innate immune system. In addition to helping the body to eliminate pathogens, however, complement activation also contributes to the pathogenesis of a wide range of kidney diseases. Recent work has revealed that uncontrolled complement activation is the key driver of several rare kidney diseases in children, including atypical hemolytic uremic syndrome and C3 glomerulopathy. In addition, a growing body of literature has implicated complement in the pathogenesis of more common kidney diseases, including acute kidney injury (AKI). Complement-targeted therapeutics are in use for a variety of diseases, and an increasing number of therapeutic agents are under development. With the implication of complement in the pathogenesis of AKI, complement-targeted therapeutics could be trialed to prevent or treat this condition. In this review, we discuss the evidence that the complement system is activated in pediatric patients with AKI, and we review the role of complement proteins as biomarkers and therapeutic targets in patients with AKI. Springer Berlin Heidelberg 2022-10-06 2023 /pmc/articles/PMC9540254/ /pubmed/36203104 http://dx.doi.org/10.1007/s00467-022-05755-3 Text en © The Author(s), under exclusive licence to International Pediatric Nephrology Association 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Stenson, Erin K. Kendrick, Jessica Dixon, Bradley Thurman, Joshua M. The complement system in pediatric acute kidney injury |
title | The complement system in pediatric acute kidney injury |
title_full | The complement system in pediatric acute kidney injury |
title_fullStr | The complement system in pediatric acute kidney injury |
title_full_unstemmed | The complement system in pediatric acute kidney injury |
title_short | The complement system in pediatric acute kidney injury |
title_sort | complement system in pediatric acute kidney injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540254/ https://www.ncbi.nlm.nih.gov/pubmed/36203104 http://dx.doi.org/10.1007/s00467-022-05755-3 |
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