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Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism
BACKGROUND AND OBJECTIVE: The pulmonary embolism severity index (PESI) and simplified PESI (sPESI) are recommended to recognize patients with acute pulmonary thromboembolism (PTE) with low prognosis risk, which is of great significance for treatment. This study aims to verify the influence of hypoca...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540334/ https://www.ncbi.nlm.nih.gov/pubmed/35297140 http://dx.doi.org/10.1111/resp.14243 |
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author | Yang, Yu‐qing Wang, Xin Zhang, Yun‐jian Chen, Yan‐fan Wang, Ling Hu, Xiao‐wen Niu, Ling Pu, Hong‐mei Zhang, Xin Zhang, Zhen Wang, Lan Chen, Fang‐wei Shi, Juhong Ji, Ying‐qun |
author_facet | Yang, Yu‐qing Wang, Xin Zhang, Yun‐jian Chen, Yan‐fan Wang, Ling Hu, Xiao‐wen Niu, Ling Pu, Hong‐mei Zhang, Xin Zhang, Zhen Wang, Lan Chen, Fang‐wei Shi, Juhong Ji, Ying‐qun |
author_sort | Yang, Yu‐qing |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: The pulmonary embolism severity index (PESI) and simplified PESI (sPESI) are recommended to recognize patients with acute pulmonary thromboembolism (PTE) with low prognosis risk, which is of great significance for treatment. This study aims to verify the influence of hypocalcaemia on the prognosis of patients with PTE and to establish a new prognosis assessment model. METHODS: This is an observational, multicentre study enrolling patients with PTE from February 2010 to June 2020 across 12 Chinese hospitals. Variables in PESI, serum calcium levels and patient survival status as of 5 July 2020 were collected. The area under the curve of the receiver operating characteristic curve, sensitivity, specificity and Youden index were used to evaluate model performance. RESULTS: In the cohort of 4196 patients with PTE, independent associations existed between hypocalcaemia and mid‐ and long‐term mortalities (p <0.05). By including hypocalcaemia, the new 30‐day death risk prediction rule, Peking Union Medical College Hospital rule (PUMCH rule), showed significantly higher specificity (0.622 [0.582, 0.661]; p <0.001) than the PESI (0.514 [0.473, 0.554]) and sPESI (0.484 [0.444, 0.525]) and similar sensitivity (0.963 [0.810, 0.999]; p = 0.161) with PESI (0.889 [0.708, 0.976]) and sPESI (0.963 [0.810, 0.999]) in the internal validation cohort. Well‐performing predictive validity was also verified on a constructed external validation cohort. CONCLUSION: Hypocalcaemia is independently associated with mid‐ and long‐term PTE mortalities. The PUMCH rule showed significantly higher specificity than the PESI and sPESI and similar sensitivity, which may be used as a prognostic assessment tool for patients with acute PTE. |
format | Online Article Text |
id | pubmed-9540334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-95403342022-10-14 Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism Yang, Yu‐qing Wang, Xin Zhang, Yun‐jian Chen, Yan‐fan Wang, Ling Hu, Xiao‐wen Niu, Ling Pu, Hong‐mei Zhang, Xin Zhang, Zhen Wang, Lan Chen, Fang‐wei Shi, Juhong Ji, Ying‐qun Respirology ORIGINAL ARTICLES BACKGROUND AND OBJECTIVE: The pulmonary embolism severity index (PESI) and simplified PESI (sPESI) are recommended to recognize patients with acute pulmonary thromboembolism (PTE) with low prognosis risk, which is of great significance for treatment. This study aims to verify the influence of hypocalcaemia on the prognosis of patients with PTE and to establish a new prognosis assessment model. METHODS: This is an observational, multicentre study enrolling patients with PTE from February 2010 to June 2020 across 12 Chinese hospitals. Variables in PESI, serum calcium levels and patient survival status as of 5 July 2020 were collected. The area under the curve of the receiver operating characteristic curve, sensitivity, specificity and Youden index were used to evaluate model performance. RESULTS: In the cohort of 4196 patients with PTE, independent associations existed between hypocalcaemia and mid‐ and long‐term mortalities (p <0.05). By including hypocalcaemia, the new 30‐day death risk prediction rule, Peking Union Medical College Hospital rule (PUMCH rule), showed significantly higher specificity (0.622 [0.582, 0.661]; p <0.001) than the PESI (0.514 [0.473, 0.554]) and sPESI (0.484 [0.444, 0.525]) and similar sensitivity (0.963 [0.810, 0.999]; p = 0.161) with PESI (0.889 [0.708, 0.976]) and sPESI (0.963 [0.810, 0.999]) in the internal validation cohort. Well‐performing predictive validity was also verified on a constructed external validation cohort. CONCLUSION: Hypocalcaemia is independently associated with mid‐ and long‐term PTE mortalities. The PUMCH rule showed significantly higher specificity than the PESI and sPESI and similar sensitivity, which may be used as a prognostic assessment tool for patients with acute PTE. John Wiley & Sons, Ltd 2022-03-16 2022-08 /pmc/articles/PMC9540334/ /pubmed/35297140 http://dx.doi.org/10.1111/resp.14243 Text en © 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | ORIGINAL ARTICLES Yang, Yu‐qing Wang, Xin Zhang, Yun‐jian Chen, Yan‐fan Wang, Ling Hu, Xiao‐wen Niu, Ling Pu, Hong‐mei Zhang, Xin Zhang, Zhen Wang, Lan Chen, Fang‐wei Shi, Juhong Ji, Ying‐qun Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
title | Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
title_full | Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
title_fullStr | Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
title_full_unstemmed | Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
title_short | Prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
title_sort | prognosis assessment model based on low serum calcium in patients with acute pulmonary thromboembolism |
topic | ORIGINAL ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540334/ https://www.ncbi.nlm.nih.gov/pubmed/35297140 http://dx.doi.org/10.1111/resp.14243 |
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