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Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment

Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non‐central nervous system (non‐CNS) tumors. MRI guidance allows for precise placement of optical fiber in the tumor, while MR thermometry provides real‐time mon...

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Autores principales: Pang, Sumiao, Kapur, Anshika, Zhou, Keri, Anastasiadis, Pavlos, Ballirano, Nicholas, Kim, Anthony J., Winkles, Jeffrey A., Woodworth, Graeme F., Huang, Huang‐Chiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540339/
https://www.ncbi.nlm.nih.gov/pubmed/35735205
http://dx.doi.org/10.1002/wnan.1826
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author Pang, Sumiao
Kapur, Anshika
Zhou, Keri
Anastasiadis, Pavlos
Ballirano, Nicholas
Kim, Anthony J.
Winkles, Jeffrey A.
Woodworth, Graeme F.
Huang, Huang‐Chiao
author_facet Pang, Sumiao
Kapur, Anshika
Zhou, Keri
Anastasiadis, Pavlos
Ballirano, Nicholas
Kim, Anthony J.
Winkles, Jeffrey A.
Woodworth, Graeme F.
Huang, Huang‐Chiao
author_sort Pang, Sumiao
collection PubMed
description Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non‐central nervous system (non‐CNS) tumors. MRI guidance allows for precise placement of optical fiber in the tumor, while MR thermometry provides real‐time monitoring and assessment of thermal doses during the procedure. Despite promising clinical results, LITT complications relating to brain tumor procedures, such as hemorrhage, edema, seizures, and thermal injury to nearby healthy tissues, remain a significant concern. To address these complications, nanoparticles offer unique prospects for precise interstitial hyperthermia applications that increase heat transport within the tumor while reducing thermal impacts on neighboring healthy tissues. Furthermore, nanoparticles permit the co‐delivery of therapeutic compounds that not only synergize with LITT, but can also improve overall effectiveness and safety. In addition, efficient heat‐generating nanoparticles with unique optical properties can enhance LITT treatments through improved real‐time imaging and thermal sensing. This review will focus on (1) types of inorganic and organic nanoparticles for LITT; (2) in vitro, in silico, and ex vivo studies that investigate nanoparticles' effect on light–tissue interactions; and (3) the role of nanoparticle formulations in advancing clinically relevant image‐guided technologies for LITT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease. Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery.
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spelling pubmed-95403392022-10-14 Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment Pang, Sumiao Kapur, Anshika Zhou, Keri Anastasiadis, Pavlos Ballirano, Nicholas Kim, Anthony J. Winkles, Jeffrey A. Woodworth, Graeme F. Huang, Huang‐Chiao Wiley Interdiscip Rev Nanomed Nanobiotechnol Focus Articles Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non‐central nervous system (non‐CNS) tumors. MRI guidance allows for precise placement of optical fiber in the tumor, while MR thermometry provides real‐time monitoring and assessment of thermal doses during the procedure. Despite promising clinical results, LITT complications relating to brain tumor procedures, such as hemorrhage, edema, seizures, and thermal injury to nearby healthy tissues, remain a significant concern. To address these complications, nanoparticles offer unique prospects for precise interstitial hyperthermia applications that increase heat transport within the tumor while reducing thermal impacts on neighboring healthy tissues. Furthermore, nanoparticles permit the co‐delivery of therapeutic compounds that not only synergize with LITT, but can also improve overall effectiveness and safety. In addition, efficient heat‐generating nanoparticles with unique optical properties can enhance LITT treatments through improved real‐time imaging and thermal sensing. This review will focus on (1) types of inorganic and organic nanoparticles for LITT; (2) in vitro, in silico, and ex vivo studies that investigate nanoparticles' effect on light–tissue interactions; and (3) the role of nanoparticle formulations in advancing clinically relevant image‐guided technologies for LITT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease. Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery. John Wiley & Sons, Inc. 2022-06-23 2022 /pmc/articles/PMC9540339/ /pubmed/35735205 http://dx.doi.org/10.1002/wnan.1826 Text en © 2022 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Focus Articles
Pang, Sumiao
Kapur, Anshika
Zhou, Keri
Anastasiadis, Pavlos
Ballirano, Nicholas
Kim, Anthony J.
Winkles, Jeffrey A.
Woodworth, Graeme F.
Huang, Huang‐Chiao
Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
title Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
title_full Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
title_fullStr Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
title_full_unstemmed Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
title_short Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
title_sort nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment
topic Focus Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540339/
https://www.ncbi.nlm.nih.gov/pubmed/35735205
http://dx.doi.org/10.1002/wnan.1826
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