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Understanding anti‐TNF treatment failure: does serum triiodothyronine‐to‐thyroxine (T3/T4) ratio predict therapeutic outcome to anti‐TNF therapies in biologic‐naïve patients with active luminal Crohn's disease?

BACKGROUND: During illness, adaptations of the hypothalamic–pituitary‐thyroid axis reduce energy expenditure, protein catabolism and modulate immune responses to promote survival. Lower serum free triiodothyronine‐to‐thyroxine (fT3/fT4) ratio has been linked to non‐response to treatment in a range o...

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Detalles Bibliográficos
Autores principales:	Lin, Simeng, Chanchlani, Neil, Carbery, Isabel, Janjua, Malik, Nice, Rachel, McDonald, Timothy J., Bewshea, Claire, Kennedy, Nicholas A., Ahmad, Tariq, Selinger, Christian P., Goodhand, James R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Thyroid Function Tests and Failure of Anti‐tnf Agents in Crohn's Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540440/ https://www.ncbi.nlm.nih.gov/pubmed/35768996 http://dx.doi.org/10.1111/apt.17089

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