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Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements

Submicron‐sized wear particles are generally accepted as a potential cause of aseptic loosening when produced in sufficient volumes. With the accelerating use of increasingly wear‐resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging...

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Autores principales: Stratton‐Powell, Ashley A., Williams, Sophie, Tipper, Joanne L., Redmond, Anthony C., Brockett, Claire L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540445/
https://www.ncbi.nlm.nih.gov/pubmed/35532138
http://dx.doi.org/10.1002/jbm.b.35076
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author Stratton‐Powell, Ashley A.
Williams, Sophie
Tipper, Joanne L.
Redmond, Anthony C.
Brockett, Claire L.
author_facet Stratton‐Powell, Ashley A.
Williams, Sophie
Tipper, Joanne L.
Redmond, Anthony C.
Brockett, Claire L.
author_sort Stratton‐Powell, Ashley A.
collection PubMed
description Submicron‐sized wear particles are generally accepted as a potential cause of aseptic loosening when produced in sufficient volumes. With the accelerating use of increasingly wear‐resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging. Highly sensitive wear particle isolation methods have been developed but these methods cannot isolate the complete spectrum of particle types present in individual tissue samples. Two established techniques were modified to create one novel method to isolate both high‐ and low‐density materials from periprosthetic tissue samples. Ten total hip replacement and eight total knee replacement tissue samples were processed. All particle types were characterized using high resolution scanning electron microscopy. UHMWPE and a range of high‐density materials were isolated from all tissue samples, including: polymethylmethacrylate, zirconium dioxide, titanium alloy, cobalt chromium alloy and stainless steel. This feasibility study demonstrates the coexistence of mixed particle types in periprosthetic tissues and provides researchers with high‐resolution images of clinically relevant wear particles that could be used as a reference for future in vitro biological response studies.
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spelling pubmed-95404452022-10-14 Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements Stratton‐Powell, Ashley A. Williams, Sophie Tipper, Joanne L. Redmond, Anthony C. Brockett, Claire L. J Biomed Mater Res B Appl Biomater Research Articles Submicron‐sized wear particles are generally accepted as a potential cause of aseptic loosening when produced in sufficient volumes. With the accelerating use of increasingly wear‐resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging. Highly sensitive wear particle isolation methods have been developed but these methods cannot isolate the complete spectrum of particle types present in individual tissue samples. Two established techniques were modified to create one novel method to isolate both high‐ and low‐density materials from periprosthetic tissue samples. Ten total hip replacement and eight total knee replacement tissue samples were processed. All particle types were characterized using high resolution scanning electron microscopy. UHMWPE and a range of high‐density materials were isolated from all tissue samples, including: polymethylmethacrylate, zirconium dioxide, titanium alloy, cobalt chromium alloy and stainless steel. This feasibility study demonstrates the coexistence of mixed particle types in periprosthetic tissues and provides researchers with high‐resolution images of clinically relevant wear particles that could be used as a reference for future in vitro biological response studies. John Wiley & Sons, Inc. 2022-05-09 2022-10 /pmc/articles/PMC9540445/ /pubmed/35532138 http://dx.doi.org/10.1002/jbm.b.35076 Text en © 2022 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Stratton‐Powell, Ashley A.
Williams, Sophie
Tipper, Joanne L.
Redmond, Anthony C.
Brockett, Claire L.
Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
title Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
title_full Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
title_fullStr Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
title_full_unstemmed Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
title_short Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
title_sort mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540445/
https://www.ncbi.nlm.nih.gov/pubmed/35532138
http://dx.doi.org/10.1002/jbm.b.35076
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