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Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center
BACKGROUND: The objective of the study was to analyze the clinical features, treatment, and outcomes of primary vaginal endodermal sinus tumor (EST) in infants and children treated in a tertiary center. METHODS: Clinical data of patients with pathologically confirmed primary vaginal EST in our hospi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540698/ https://www.ncbi.nlm.nih.gov/pubmed/36207682 http://dx.doi.org/10.1186/s12887-022-03634-2 |
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author | Yin, Min Yang, Jiaxin Wang, Tao Li, Sijian Zhang, Xinyue |
author_facet | Yin, Min Yang, Jiaxin Wang, Tao Li, Sijian Zhang, Xinyue |
author_sort | Yin, Min |
collection | PubMed |
description | BACKGROUND: The objective of the study was to analyze the clinical features, treatment, and outcomes of primary vaginal endodermal sinus tumor (EST) in infants and children treated in a tertiary center. METHODS: Clinical data of patients with pathologically confirmed primary vaginal EST in our hospital from January 1997 to December 2017 were retrospectively reviewed and analyzed. RESULTS: A total of 21 patients were included in this study. The median age at diagnosis was 11 months (range, 4–44 months). The most common manifestations were abnormal vaginal bleeding, and a polypoid mass protruding from the vagina. Chemotherapy based on PEB (cisplatin, etoposide, bleomycin) regimen was given, and serum alpha-fetoprotein (AFP) levels dropped to normal levels after 2 to 4 cycles of chemotherapy (median, 2 cycles). After 3 to 13 cycles of chemotherapy, with a median of 5 cycles, 20 patients achieved complete remission (95.2%). The median follow-up time was 80 months (range, 4-281months). At the time of the last follow-up, 19 cases were alive without disease, and the survival rate was 90.5%. CONCLUSION: Vaginal EST is a very rare malignant germ cell tumor and is sensitive to chemotherapy. Conservative surgery combined with PEB chemotherapy is an effective way of treatment. Serum AFP and imaging examinations can monitor the treatment response and recurrence. |
format | Online Article Text |
id | pubmed-9540698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95406982022-10-08 Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center Yin, Min Yang, Jiaxin Wang, Tao Li, Sijian Zhang, Xinyue BMC Pediatr Research BACKGROUND: The objective of the study was to analyze the clinical features, treatment, and outcomes of primary vaginal endodermal sinus tumor (EST) in infants and children treated in a tertiary center. METHODS: Clinical data of patients with pathologically confirmed primary vaginal EST in our hospital from January 1997 to December 2017 were retrospectively reviewed and analyzed. RESULTS: A total of 21 patients were included in this study. The median age at diagnosis was 11 months (range, 4–44 months). The most common manifestations were abnormal vaginal bleeding, and a polypoid mass protruding from the vagina. Chemotherapy based on PEB (cisplatin, etoposide, bleomycin) regimen was given, and serum alpha-fetoprotein (AFP) levels dropped to normal levels after 2 to 4 cycles of chemotherapy (median, 2 cycles). After 3 to 13 cycles of chemotherapy, with a median of 5 cycles, 20 patients achieved complete remission (95.2%). The median follow-up time was 80 months (range, 4-281months). At the time of the last follow-up, 19 cases were alive without disease, and the survival rate was 90.5%. CONCLUSION: Vaginal EST is a very rare malignant germ cell tumor and is sensitive to chemotherapy. Conservative surgery combined with PEB chemotherapy is an effective way of treatment. Serum AFP and imaging examinations can monitor the treatment response and recurrence. BioMed Central 2022-10-07 /pmc/articles/PMC9540698/ /pubmed/36207682 http://dx.doi.org/10.1186/s12887-022-03634-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yin, Min Yang, Jiaxin Wang, Tao Li, Sijian Zhang, Xinyue Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
title | Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
title_full | Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
title_fullStr | Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
title_full_unstemmed | Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
title_short | Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
title_sort | primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540698/ https://www.ncbi.nlm.nih.gov/pubmed/36207682 http://dx.doi.org/10.1186/s12887-022-03634-2 |
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