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Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications

Endometriosis patients experience debilitating chronic pain, and the first-line treatment is ineffective at managing symptoms. Although surgical removal of the lesions provides temporary relief, more than 50% of the patients experience disease recurrence. Despite being a leading cause of hysterectom...

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Autores principales: Lingegowda, Harshavardhan, Williams, Bailey J., Spiess, Katherine G., Sisnett, Danielle J., Lomax, Alan E., Koti, Madhuri, Tayade, Chandrakant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540712/
https://www.ncbi.nlm.nih.gov/pubmed/36207747
http://dx.doi.org/10.1186/s42238-022-00163-8
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author Lingegowda, Harshavardhan
Williams, Bailey J.
Spiess, Katherine G.
Sisnett, Danielle J.
Lomax, Alan E.
Koti, Madhuri
Tayade, Chandrakant
author_facet Lingegowda, Harshavardhan
Williams, Bailey J.
Spiess, Katherine G.
Sisnett, Danielle J.
Lomax, Alan E.
Koti, Madhuri
Tayade, Chandrakant
author_sort Lingegowda, Harshavardhan
collection PubMed
description Endometriosis patients experience debilitating chronic pain, and the first-line treatment is ineffective at managing symptoms. Although surgical removal of the lesions provides temporary relief, more than 50% of the patients experience disease recurrence. Despite being a leading cause of hysterectomy, endometriosis lacks satisfactory treatments and a cure. Another challenge is the poor understanding of disease pathophysiology which adds to the delays in diagnosis and overall compromised quality of life. Endometriosis patients are in dire need of an effective therapeutic strategy that is both economical and effective in managing symptoms, while fertility is unaffected. Endocannabinoids and phytocannabinoids possess anti-inflammatory, anti-nociceptive, and anti-proliferative properties that may prove beneficial for endometriosis management, given that inflammation, vascularization, and pain are hallmark features of endometriosis. Endocannabinoids are a complex network of molecules that play a central role in physiological processes including homeostasis and tissue repair, but endocannabinoids have also been associated in the pathophysiology of several chronic inflammatory diseases including endometriosis and cancers. The lack of satisfactory treatment options combined with the recent legalization of recreational cannabinoids in some parts of the world has led to a rise in self-management strategies including the use of cannabinoids for endometriosis-related pain and other symptoms. In this review, we provide a comprehensive overview of endocannabinoids with a focus on their potential roles in the pathophysiology of endometriosis. We further provide evidence-driven perspectives on the current state of knowledge on endometriosis-associated pain, inflammation, and therapeutic avenues exploiting the endocannabinoid system for its management.
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spelling pubmed-95407122022-10-08 Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications Lingegowda, Harshavardhan Williams, Bailey J. Spiess, Katherine G. Sisnett, Danielle J. Lomax, Alan E. Koti, Madhuri Tayade, Chandrakant J Cannabis Res Review Endometriosis patients experience debilitating chronic pain, and the first-line treatment is ineffective at managing symptoms. Although surgical removal of the lesions provides temporary relief, more than 50% of the patients experience disease recurrence. Despite being a leading cause of hysterectomy, endometriosis lacks satisfactory treatments and a cure. Another challenge is the poor understanding of disease pathophysiology which adds to the delays in diagnosis and overall compromised quality of life. Endometriosis patients are in dire need of an effective therapeutic strategy that is both economical and effective in managing symptoms, while fertility is unaffected. Endocannabinoids and phytocannabinoids possess anti-inflammatory, anti-nociceptive, and anti-proliferative properties that may prove beneficial for endometriosis management, given that inflammation, vascularization, and pain are hallmark features of endometriosis. Endocannabinoids are a complex network of molecules that play a central role in physiological processes including homeostasis and tissue repair, but endocannabinoids have also been associated in the pathophysiology of several chronic inflammatory diseases including endometriosis and cancers. The lack of satisfactory treatment options combined with the recent legalization of recreational cannabinoids in some parts of the world has led to a rise in self-management strategies including the use of cannabinoids for endometriosis-related pain and other symptoms. In this review, we provide a comprehensive overview of endocannabinoids with a focus on their potential roles in the pathophysiology of endometriosis. We further provide evidence-driven perspectives on the current state of knowledge on endometriosis-associated pain, inflammation, and therapeutic avenues exploiting the endocannabinoid system for its management. BioMed Central 2022-10-07 /pmc/articles/PMC9540712/ /pubmed/36207747 http://dx.doi.org/10.1186/s42238-022-00163-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Lingegowda, Harshavardhan
Williams, Bailey J.
Spiess, Katherine G.
Sisnett, Danielle J.
Lomax, Alan E.
Koti, Madhuri
Tayade, Chandrakant
Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
title Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
title_full Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
title_fullStr Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
title_full_unstemmed Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
title_short Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
title_sort role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540712/
https://www.ncbi.nlm.nih.gov/pubmed/36207747
http://dx.doi.org/10.1186/s42238-022-00163-8
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