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The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy
BACKGROUND: Previous findings indicated that breast cancer patients often have dysfunction in empathy and other cognitive functions during or after chemotherapy. However, the manifestations and possible neuro-electrophysiological mechanisms of pain empathy impairment in breast cancer patients after...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540992/ https://www.ncbi.nlm.nih.gov/pubmed/36211858 http://dx.doi.org/10.3389/fpsyg.2022.942036 |
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author | Li, Wen Lv, Yue Duan, Xu Cheng, Guo Yao, Senbang Yu, Sheng Tang, Lingxue Cheng, Huaidong |
author_facet | Li, Wen Lv, Yue Duan, Xu Cheng, Guo Yao, Senbang Yu, Sheng Tang, Lingxue Cheng, Huaidong |
author_sort | Li, Wen |
collection | PubMed |
description | BACKGROUND: Previous findings indicated that breast cancer patients often have dysfunction in empathy and other cognitive functions during or after chemotherapy. However, the manifestations and possible neuro-electrophysiological mechanisms of pain empathy impairment in breast cancer patients after chemotherapy were still unknown. OBJECTIVE: The current study aimed to investigate the potential correlations between pain empathy impairment and event-related potentials (ERP) in breast cancer patients undergoing chemotherapy. METHODS: Twenty-two breast cancer patients were evaluated on a neuropsychological test and pain empathy paradigm before and after chemotherapy, containing the Chinese version of the Interpersonal Reactivity Index (IRI-C), while recording ERP data. RESULTS: The empathic concern scores were lower and personal distress scores were higher on IRI-C task compared with those before chemotherapy (t = 3.039, p < 0.01; t = −2.324, p < 0.05, respectively). Meanwhile, the accuracy rates were lower than those before chemotherapy for both pain and laterality tasks on the pain empathy paradigm (F = 5.099, P = 0.035). However, the response time was no significant differences before and after chemotherapy (F = 0.543, P = 0.469). Further, the amplitude of the N1 component was significantly increased (F = 38.091, P < 0.001), and the amplitude of the P2 component was significantly decreased (F = 15.046, P = 0.001) in the subsequent ERP study. A linear mixed effect model was used to analyze the correlation, the average amplitude of N1 and P2 were positively correlated with the accuracy rates in laterality tasks (r = 1.765, r = 1.125, respectively, P < 0.05). CONCLUSION: The results indicated that pain empathy impairment was performed in chemotherapeutic breast cancer patients, which was possibly correlated to the changes of N1 and P2 components in ERP. These findings provide neuro-electrophysiological information about chemo-brain in breast cancer patients. |
format | Online Article Text |
id | pubmed-9540992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95409922022-10-08 The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy Li, Wen Lv, Yue Duan, Xu Cheng, Guo Yao, Senbang Yu, Sheng Tang, Lingxue Cheng, Huaidong Front Psychol Psychology BACKGROUND: Previous findings indicated that breast cancer patients often have dysfunction in empathy and other cognitive functions during or after chemotherapy. However, the manifestations and possible neuro-electrophysiological mechanisms of pain empathy impairment in breast cancer patients after chemotherapy were still unknown. OBJECTIVE: The current study aimed to investigate the potential correlations between pain empathy impairment and event-related potentials (ERP) in breast cancer patients undergoing chemotherapy. METHODS: Twenty-two breast cancer patients were evaluated on a neuropsychological test and pain empathy paradigm before and after chemotherapy, containing the Chinese version of the Interpersonal Reactivity Index (IRI-C), while recording ERP data. RESULTS: The empathic concern scores were lower and personal distress scores were higher on IRI-C task compared with those before chemotherapy (t = 3.039, p < 0.01; t = −2.324, p < 0.05, respectively). Meanwhile, the accuracy rates were lower than those before chemotherapy for both pain and laterality tasks on the pain empathy paradigm (F = 5.099, P = 0.035). However, the response time was no significant differences before and after chemotherapy (F = 0.543, P = 0.469). Further, the amplitude of the N1 component was significantly increased (F = 38.091, P < 0.001), and the amplitude of the P2 component was significantly decreased (F = 15.046, P = 0.001) in the subsequent ERP study. A linear mixed effect model was used to analyze the correlation, the average amplitude of N1 and P2 were positively correlated with the accuracy rates in laterality tasks (r = 1.765, r = 1.125, respectively, P < 0.05). CONCLUSION: The results indicated that pain empathy impairment was performed in chemotherapeutic breast cancer patients, which was possibly correlated to the changes of N1 and P2 components in ERP. These findings provide neuro-electrophysiological information about chemo-brain in breast cancer patients. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9540992/ /pubmed/36211858 http://dx.doi.org/10.3389/fpsyg.2022.942036 Text en Copyright © 2022 Li, Lv, Duan, Cheng, Yao, Yu, Tang and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Li, Wen Lv, Yue Duan, Xu Cheng, Guo Yao, Senbang Yu, Sheng Tang, Lingxue Cheng, Huaidong The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
title | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
title_full | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
title_fullStr | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
title_full_unstemmed | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
title_short | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
title_sort | alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540992/ https://www.ncbi.nlm.nih.gov/pubmed/36211858 http://dx.doi.org/10.3389/fpsyg.2022.942036 |
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