LINC00467: an oncogenic long noncoding RNA

Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest in exploring the relationship between lncRNAs and tumors. Many latest evidences revealed tha...

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Autores principales: Chen, Xuyu, Luo, Qian, Xiao, Yanan, Zhu, Jing, Zhang, Yirao, Ding, Jie, Li, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541002/
https://www.ncbi.nlm.nih.gov/pubmed/36203193
http://dx.doi.org/10.1186/s12935-022-02733-5
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author Chen, Xuyu
Luo, Qian
Xiao, Yanan
Zhu, Jing
Zhang, Yirao
Ding, Jie
Li, Juan
author_facet Chen, Xuyu
Luo, Qian
Xiao, Yanan
Zhu, Jing
Zhang, Yirao
Ding, Jie
Li, Juan
author_sort Chen, Xuyu
collection PubMed
description Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest in exploring the relationship between lncRNAs and tumors. Many latest evidences revealed that LINC00467, an oncogenic lncRNA, is highly expressed in lung cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, breast cancer, glioblastoma, head and neck squamous cell carcinoma, osteosarcoma, and other malignant tumors. Besides, LINC00467 expression was linked with proliferation, migration, invasion and apoptosis via the regulation of target genes and multiple potential pathways. We reviewed the existing data on the expression, downstream targets, molecular mechanisms, functions, relevant signaling pathways, and clinical implications of LINC00467 in various cancers. LINC00467 may serve as a novel biomarker or therapeutic target for the diagnosis and prognosis of various human tumors.
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spelling pubmed-95410022022-10-08 LINC00467: an oncogenic long noncoding RNA Chen, Xuyu Luo, Qian Xiao, Yanan Zhu, Jing Zhang, Yirao Ding, Jie Li, Juan Cancer Cell Int Review Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest in exploring the relationship between lncRNAs and tumors. Many latest evidences revealed that LINC00467, an oncogenic lncRNA, is highly expressed in lung cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, breast cancer, glioblastoma, head and neck squamous cell carcinoma, osteosarcoma, and other malignant tumors. Besides, LINC00467 expression was linked with proliferation, migration, invasion and apoptosis via the regulation of target genes and multiple potential pathways. We reviewed the existing data on the expression, downstream targets, molecular mechanisms, functions, relevant signaling pathways, and clinical implications of LINC00467 in various cancers. LINC00467 may serve as a novel biomarker or therapeutic target for the diagnosis and prognosis of various human tumors. BioMed Central 2022-10-07 /pmc/articles/PMC9541002/ /pubmed/36203193 http://dx.doi.org/10.1186/s12935-022-02733-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Xuyu
Luo, Qian
Xiao, Yanan
Zhu, Jing
Zhang, Yirao
Ding, Jie
Li, Juan
LINC00467: an oncogenic long noncoding RNA
title LINC00467: an oncogenic long noncoding RNA
title_full LINC00467: an oncogenic long noncoding RNA
title_fullStr LINC00467: an oncogenic long noncoding RNA
title_full_unstemmed LINC00467: an oncogenic long noncoding RNA
title_short LINC00467: an oncogenic long noncoding RNA
title_sort linc00467: an oncogenic long noncoding rna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541002/
https://www.ncbi.nlm.nih.gov/pubmed/36203193
http://dx.doi.org/10.1186/s12935-022-02733-5
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AT zhangyirao linc00467anoncogeniclongnoncodingrna
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