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Traumatic Brain Injury and Secondary Neurodegenerative Disease

Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear t...

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Autores principales: Dodd, William S., Panther, Eric J., Pierre, Kevin, Hernandez, Jairo S., Patel, Devan, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541088/
https://www.ncbi.nlm.nih.gov/pubmed/36211982
http://dx.doi.org/10.3390/traumacare2040042
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author Dodd, William S.
Panther, Eric J.
Pierre, Kevin
Hernandez, Jairo S.
Patel, Devan
Lucke-Wold, Brandon
author_facet Dodd, William S.
Panther, Eric J.
Pierre, Kevin
Hernandez, Jairo S.
Patel, Devan
Lucke-Wold, Brandon
author_sort Dodd, William S.
collection PubMed
description Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson’s disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury. The complex nature of these pathologies can make clinical assessment, diagnosis, and treatment challenging. The goal of this review is to provide a concise appraisal of the literature with focus on emerging strategies to improve clinical outcomes. First, we review the pathways involved in the pathogenesis of neurotrauma-related neurodegeneration and discuss the clinical implications of this rapidly evolving field. Next, because clinical evaluation and neuroimaging are essential to the diagnosis and management of neurodegenerative diseases, we analyze the clinical investigations that are transforming these areas of research. Finally, we briefly review some of the preclinical therapies that have shown the most promise in improving outcomes after neurotrauma.
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spelling pubmed-95410882022-12-01 Traumatic Brain Injury and Secondary Neurodegenerative Disease Dodd, William S. Panther, Eric J. Pierre, Kevin Hernandez, Jairo S. Patel, Devan Lucke-Wold, Brandon Trauma Care (Basel) Article Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson’s disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury. The complex nature of these pathologies can make clinical assessment, diagnosis, and treatment challenging. The goal of this review is to provide a concise appraisal of the literature with focus on emerging strategies to improve clinical outcomes. First, we review the pathways involved in the pathogenesis of neurotrauma-related neurodegeneration and discuss the clinical implications of this rapidly evolving field. Next, because clinical evaluation and neuroimaging are essential to the diagnosis and management of neurodegenerative diseases, we analyze the clinical investigations that are transforming these areas of research. Finally, we briefly review some of the preclinical therapies that have shown the most promise in improving outcomes after neurotrauma. 2022-12 2022-09-26 /pmc/articles/PMC9541088/ /pubmed/36211982 http://dx.doi.org/10.3390/traumacare2040042 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dodd, William S.
Panther, Eric J.
Pierre, Kevin
Hernandez, Jairo S.
Patel, Devan
Lucke-Wold, Brandon
Traumatic Brain Injury and Secondary Neurodegenerative Disease
title Traumatic Brain Injury and Secondary Neurodegenerative Disease
title_full Traumatic Brain Injury and Secondary Neurodegenerative Disease
title_fullStr Traumatic Brain Injury and Secondary Neurodegenerative Disease
title_full_unstemmed Traumatic Brain Injury and Secondary Neurodegenerative Disease
title_short Traumatic Brain Injury and Secondary Neurodegenerative Disease
title_sort traumatic brain injury and secondary neurodegenerative disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541088/
https://www.ncbi.nlm.nih.gov/pubmed/36211982
http://dx.doi.org/10.3390/traumacare2040042
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