Cargando…

Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study

Climatotherapy is a well‐described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient‐reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate...

Descripción completa

Detalles Bibliográficos
Autores principales: Emmanuel, Thomas, Petersen, Annita, Houborg, Hannah Inez, Rønsholdt, Anders Benjamin, Lybæk, Dorte, Steiniche, Torben, Bregnhøj, Anne, Iversen, Lars, Johansen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541097/
https://www.ncbi.nlm.nih.gov/pubmed/35196397
http://dx.doi.org/10.1111/exd.14549
_version_ 1784803849573236736
author Emmanuel, Thomas
Petersen, Annita
Houborg, Hannah Inez
Rønsholdt, Anders Benjamin
Lybæk, Dorte
Steiniche, Torben
Bregnhøj, Anne
Iversen, Lars
Johansen, Claus
author_facet Emmanuel, Thomas
Petersen, Annita
Houborg, Hannah Inez
Rønsholdt, Anders Benjamin
Lybæk, Dorte
Steiniche, Torben
Bregnhøj, Anne
Iversen, Lars
Johansen, Claus
author_sort Emmanuel, Thomas
collection PubMed
description Climatotherapy is a well‐described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient‐reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate the effect of DSC on psoriasis skin using quantitative immunohistochemistry techniques and analysis of blood samples. Skin punch biopsies from 18 psoriasis patients from a previous cohort study were used. Biopsies were obtained from non‐lesional skin and from a psoriasis target lesion at baseline. A biopsy was acquired from the target lesion after DSC. Among patients who achieved complete visual clearance, a biopsy was also obtained at relapse. Blood samples were obtained at the same time points. We performed haematoxylin and eosin staining and quantitative immunohistochemical analysis of CD3, CD4, CD8, CD11c, CD103, CD163, CD207, forkhead box P3, Ki67 and myeloperoxidase. We performed blood tests of cholesterol, c‐reactive protein, glucose, haemoglobin A1c and triglycerides. All skin biomarkers except for CD207 were decreased after DSC. At relapse, none of the biomarkers were significantly different from the baseline lesional measurements. Total CD207 staining correlated with psoriasis area and severity index at baseline while CD163 staining correlated with psoriasis area and severity index at EOT. No changes were observed in selected blood tests during the study. Consistent with clinical results, DSC is highly effective in the short term almost normalising all investigated biomarkers. However, at relapse, biomarkers were upregulated to the baseline level.
format Online
Article
Text
id pubmed-9541097
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-95410972022-10-14 Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study Emmanuel, Thomas Petersen, Annita Houborg, Hannah Inez Rønsholdt, Anders Benjamin Lybæk, Dorte Steiniche, Torben Bregnhøj, Anne Iversen, Lars Johansen, Claus Exp Dermatol Research Articles Climatotherapy is a well‐described treatment of psoriasis. Dead Sea climatotherapy (DSC) in Israel consists of intensive sun and Dead Sea bathing and is very effective in improving clinical and patient‐reported outcomes. However, the effect of DSC has not been widely studied. We aimed to investigate the effect of DSC on psoriasis skin using quantitative immunohistochemistry techniques and analysis of blood samples. Skin punch biopsies from 18 psoriasis patients from a previous cohort study were used. Biopsies were obtained from non‐lesional skin and from a psoriasis target lesion at baseline. A biopsy was acquired from the target lesion after DSC. Among patients who achieved complete visual clearance, a biopsy was also obtained at relapse. Blood samples were obtained at the same time points. We performed haematoxylin and eosin staining and quantitative immunohistochemical analysis of CD3, CD4, CD8, CD11c, CD103, CD163, CD207, forkhead box P3, Ki67 and myeloperoxidase. We performed blood tests of cholesterol, c‐reactive protein, glucose, haemoglobin A1c and triglycerides. All skin biomarkers except for CD207 were decreased after DSC. At relapse, none of the biomarkers were significantly different from the baseline lesional measurements. Total CD207 staining correlated with psoriasis area and severity index at baseline while CD163 staining correlated with psoriasis area and severity index at EOT. No changes were observed in selected blood tests during the study. Consistent with clinical results, DSC is highly effective in the short term almost normalising all investigated biomarkers. However, at relapse, biomarkers were upregulated to the baseline level. John Wiley and Sons Inc. 2022-02-27 2022-08 /pmc/articles/PMC9541097/ /pubmed/35196397 http://dx.doi.org/10.1111/exd.14549 Text en © 2022 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Emmanuel, Thomas
Petersen, Annita
Houborg, Hannah Inez
Rønsholdt, Anders Benjamin
Lybæk, Dorte
Steiniche, Torben
Bregnhøj, Anne
Iversen, Lars
Johansen, Claus
Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study
title Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study
title_full Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study
title_fullStr Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study
title_full_unstemmed Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study
title_short Climatotherapy at the Dead Sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: An immunohistochemical study
title_sort climatotherapy at the dead sea for psoriasis is a highly effective anti‐inflammatory treatment in the short term: an immunohistochemical study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541097/
https://www.ncbi.nlm.nih.gov/pubmed/35196397
http://dx.doi.org/10.1111/exd.14549
work_keys_str_mv AT emmanuelthomas climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT petersenannita climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT houborghannahinez climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT rønsholdtandersbenjamin climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT lybækdorte climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT steinichetorben climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT bregnhøjanne climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT iversenlars climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy
AT johansenclaus climatotherapyatthedeadseaforpsoriasisisahighlyeffectiveantiinflammatorytreatmentintheshorttermanimmunohistochemicalstudy