An optimized platform for efficient siRNA delivery into human NK cells

The molecular networks that regulate natural killer (NK) cell functions are not completely understood. Here, we present a workflow for efficient delivery of siRNA into human NK cells without compromising viability. This methodology represents a promising approach for rapidly interrogating gene funct...

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Detalles Bibliográficos
Autores principales: Palacios, Daniel, Momayyezi, Pouria, Huhn, Oisín, Ask, Eivind Heggernes, Dunst, Josefine, Malmberg, Karl‐Johan, Hammer, Quirin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541389/
https://www.ncbi.nlm.nih.gov/pubmed/35416292
http://dx.doi.org/10.1002/eji.202149710
Descripción
Sumario:The molecular networks that regulate natural killer (NK) cell functions are not completely understood. Here, we present a workflow for efficient delivery of siRNA into human NK cells without compromising viability. This methodology represents a promising approach for rapidly interrogating gene functions in primary human NK cells. [Image: see text]

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