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Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies
OBJECTIVE: To examine the relationship between metabolically healthy and unhealthy obesity phenotypes and risk of vasomotor symptoms (VMS) in premenopausal women. DESIGN: Prospective cohort study. SETTING: Middle‐aged women in a cohort based on regular health screening examinations. POPULATION: Prem...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541406/ https://www.ncbi.nlm.nih.gov/pubmed/35596933 http://dx.doi.org/10.1111/1471-0528.17224 |
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author | Namgoung, Sunju Chang, Yoosoo Woo, Chae‐Yeon Kim, Yejin Kang, Jeonggyu Kwon, Ria Lim, Ga‐Young Choi, Hye Rin Kim, Kye‐Hyun Kim, Hoon Hong, Yun Soo Zhao, Di Cho, Juhee Guallar, Eliseo Park, Hyun‐Young Ryu, Seungho |
author_facet | Namgoung, Sunju Chang, Yoosoo Woo, Chae‐Yeon Kim, Yejin Kang, Jeonggyu Kwon, Ria Lim, Ga‐Young Choi, Hye Rin Kim, Kye‐Hyun Kim, Hoon Hong, Yun Soo Zhao, Di Cho, Juhee Guallar, Eliseo Park, Hyun‐Young Ryu, Seungho |
author_sort | Namgoung, Sunju |
collection | PubMed |
description | OBJECTIVE: To examine the relationship between metabolically healthy and unhealthy obesity phenotypes and risk of vasomotor symptoms (VMS) in premenopausal women. DESIGN: Prospective cohort study. SETTING: Middle‐aged women in a cohort based on regular health screening examinations. POPULATION: Premenopausal Korean women aged 42–52 years were recruited and were followed up for a median of 4.2 years. The cross‐sectional and cohort studies comprised 4672 women and 2590 women without VMS at baseline, respectively. METHODS: Adiposity measures included body mass index (BMI), waist circumference and percentage body fat. Being metabolically healthy was defined as not having any metabolic syndrome components or a homeostasis model assessment of insulin resistance of 2.5 or more. MAIN OUTCOMES MEASURES: VMS (hot flushes and night sweats) assessed using the questionnaire. RESULTS: All adiposity measures were positively associated with an increased risk of VMS in both cross‐sectional and longitudinal studies. The multivariable‐adjusted prevalence ratio (95% confidence interval [CI]) for VMS comparing percentage body fat of 35% or more with the reference was 1.47 (95% CI 1.14–1.90) in metabolically healthy women, and the corresponding prevalence ratio was 2.32 (95% CI 1.42–3.78) in metabolically unhealthy women (P (interaction) = 0.334). The multivariable‐adjusted hazard ratio for incident VMS comparing percentage body fat of 35% or more with the reference was 1.34 (95% CI 1.00–1.79) in metabolically healthy women, whereas the corresponding hazard ratio was 3.61 (95% CI 1.81–7.20) in metabolically unhealthy women (P (interaction) = 0.036). The association between BMI, waist circumference and VMS did not significantly differ by metabolic health status. CONCLUSIONS: Maintaining normal weight and being metabolically healthy may help to prevent VMS in premenopausal women. TWEETABLE ABSTRACT: Avoiding obesity and a metabolically unhealthy status may help reduce vasomotor symptoms in premenopausal women. |
format | Online Article Text |
id | pubmed-9541406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95414062022-10-14 Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies Namgoung, Sunju Chang, Yoosoo Woo, Chae‐Yeon Kim, Yejin Kang, Jeonggyu Kwon, Ria Lim, Ga‐Young Choi, Hye Rin Kim, Kye‐Hyun Kim, Hoon Hong, Yun Soo Zhao, Di Cho, Juhee Guallar, Eliseo Park, Hyun‐Young Ryu, Seungho BJOG Research Articles OBJECTIVE: To examine the relationship between metabolically healthy and unhealthy obesity phenotypes and risk of vasomotor symptoms (VMS) in premenopausal women. DESIGN: Prospective cohort study. SETTING: Middle‐aged women in a cohort based on regular health screening examinations. POPULATION: Premenopausal Korean women aged 42–52 years were recruited and were followed up for a median of 4.2 years. The cross‐sectional and cohort studies comprised 4672 women and 2590 women without VMS at baseline, respectively. METHODS: Adiposity measures included body mass index (BMI), waist circumference and percentage body fat. Being metabolically healthy was defined as not having any metabolic syndrome components or a homeostasis model assessment of insulin resistance of 2.5 or more. MAIN OUTCOMES MEASURES: VMS (hot flushes and night sweats) assessed using the questionnaire. RESULTS: All adiposity measures were positively associated with an increased risk of VMS in both cross‐sectional and longitudinal studies. The multivariable‐adjusted prevalence ratio (95% confidence interval [CI]) for VMS comparing percentage body fat of 35% or more with the reference was 1.47 (95% CI 1.14–1.90) in metabolically healthy women, and the corresponding prevalence ratio was 2.32 (95% CI 1.42–3.78) in metabolically unhealthy women (P (interaction) = 0.334). The multivariable‐adjusted hazard ratio for incident VMS comparing percentage body fat of 35% or more with the reference was 1.34 (95% CI 1.00–1.79) in metabolically healthy women, whereas the corresponding hazard ratio was 3.61 (95% CI 1.81–7.20) in metabolically unhealthy women (P (interaction) = 0.036). The association between BMI, waist circumference and VMS did not significantly differ by metabolic health status. CONCLUSIONS: Maintaining normal weight and being metabolically healthy may help to prevent VMS in premenopausal women. TWEETABLE ABSTRACT: Avoiding obesity and a metabolically unhealthy status may help reduce vasomotor symptoms in premenopausal women. John Wiley and Sons Inc. 2022-06-07 2022-10 /pmc/articles/PMC9541406/ /pubmed/35596933 http://dx.doi.org/10.1111/1471-0528.17224 Text en © 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Namgoung, Sunju Chang, Yoosoo Woo, Chae‐Yeon Kim, Yejin Kang, Jeonggyu Kwon, Ria Lim, Ga‐Young Choi, Hye Rin Kim, Kye‐Hyun Kim, Hoon Hong, Yun Soo Zhao, Di Cho, Juhee Guallar, Eliseo Park, Hyun‐Young Ryu, Seungho Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
title | Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
title_full | Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
title_fullStr | Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
title_full_unstemmed | Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
title_short | Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
title_sort | metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541406/ https://www.ncbi.nlm.nih.gov/pubmed/35596933 http://dx.doi.org/10.1111/1471-0528.17224 |
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