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Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal

The objective of this study was to identify factors that predict for sperm granuloma formation and the impact of sperm granuloma presence and quantity on vasectomy reversal (VR) outcomes. A cross sectional retrospective review of prospectively collected data, on the impact of granuloma on VR outcome...

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Autores principales: Samplaski, Mary K., Rodman, John C. S., Perry, Jessica Michelle, Marks, Matthew B. F., Zollman, Robert, Asanad, Kian, Marks, Sheldon F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541413/
https://www.ncbi.nlm.nih.gov/pubmed/35524153
http://dx.doi.org/10.1111/and.14439
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author Samplaski, Mary K.
Rodman, John C. S.
Perry, Jessica Michelle
Marks, Matthew B. F.
Zollman, Robert
Asanad, Kian
Marks, Sheldon F.
author_facet Samplaski, Mary K.
Rodman, John C. S.
Perry, Jessica Michelle
Marks, Matthew B. F.
Zollman, Robert
Asanad, Kian
Marks, Sheldon F.
author_sort Samplaski, Mary K.
collection PubMed
description The objective of this study was to identify factors that predict for sperm granuloma formation and the impact of sperm granuloma presence and quantity on vasectomy reversal (VR) outcomes. A cross sectional retrospective review of prospectively collected data, on the impact of granuloma on VR outcomes from a single academic center was performed. The impact of age, obstructive interval, intraoperative vasal fluid findings, anastomosis type, body mass index, tobacco use and total motile count (TMC) was determined. A total of 1550 men underwent VR between January 2000 and August 2019. Granulomas were present unilaterally in 23.3% (n = 361) and bilaterally in 14.2% (n = 220). On univariate analysis, increasing patient age negatively correlated with a larger number of granulomas (p = .011). Granuloma presence was associated with finding intact and motile sperm from the vasal stump intraoperatively (p = .001), and vasoepididymostomy anastomosis (p < .001). However, granuloma presence (and quantity) did not correlate with obstructive interval or maximum TMC. Tobacco use and body mass index (BMI) were not associated with granuloma presence. On multivariate analysis, granuloma quantity was not associated with TMC. Obstructive interval and vasovasostomy anastomosis were associated with higher TMC, while BMI was negatively associated with TMC. In conclusion, increasing age was negatively correlated with granuloma formation. Granuloma presence was associated with more favourable intraoperative fluid findings and anastomosis type, but not post‐VR TMC, suggesting men with and without granulomas undergoing skilled microsurgery will have similar patency rates. Heavier men should be encouraged for weight loss prior to vasectomy reversal as increasing BMI was associated with lower TMC.
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spelling pubmed-95414132022-10-14 Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal Samplaski, Mary K. Rodman, John C. S. Perry, Jessica Michelle Marks, Matthew B. F. Zollman, Robert Asanad, Kian Marks, Sheldon F. Andrologia Original Articles The objective of this study was to identify factors that predict for sperm granuloma formation and the impact of sperm granuloma presence and quantity on vasectomy reversal (VR) outcomes. A cross sectional retrospective review of prospectively collected data, on the impact of granuloma on VR outcomes from a single academic center was performed. The impact of age, obstructive interval, intraoperative vasal fluid findings, anastomosis type, body mass index, tobacco use and total motile count (TMC) was determined. A total of 1550 men underwent VR between January 2000 and August 2019. Granulomas were present unilaterally in 23.3% (n = 361) and bilaterally in 14.2% (n = 220). On univariate analysis, increasing patient age negatively correlated with a larger number of granulomas (p = .011). Granuloma presence was associated with finding intact and motile sperm from the vasal stump intraoperatively (p = .001), and vasoepididymostomy anastomosis (p < .001). However, granuloma presence (and quantity) did not correlate with obstructive interval or maximum TMC. Tobacco use and body mass index (BMI) were not associated with granuloma presence. On multivariate analysis, granuloma quantity was not associated with TMC. Obstructive interval and vasovasostomy anastomosis were associated with higher TMC, while BMI was negatively associated with TMC. In conclusion, increasing age was negatively correlated with granuloma formation. Granuloma presence was associated with more favourable intraoperative fluid findings and anastomosis type, but not post‐VR TMC, suggesting men with and without granulomas undergoing skilled microsurgery will have similar patency rates. Heavier men should be encouraged for weight loss prior to vasectomy reversal as increasing BMI was associated with lower TMC. John Wiley and Sons Inc. 2022-05-06 2022-08 /pmc/articles/PMC9541413/ /pubmed/35524153 http://dx.doi.org/10.1111/and.14439 Text en © 2022 The Authors. Andrologia published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Samplaski, Mary K.
Rodman, John C. S.
Perry, Jessica Michelle
Marks, Matthew B. F.
Zollman, Robert
Asanad, Kian
Marks, Sheldon F.
Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal
title Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal
title_full Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal
title_fullStr Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal
title_full_unstemmed Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal
title_short Sperm granulomas: Predictive factors and impacts on patency post vasectomy reversal
title_sort sperm granulomas: predictive factors and impacts on patency post vasectomy reversal
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541413/
https://www.ncbi.nlm.nih.gov/pubmed/35524153
http://dx.doi.org/10.1111/and.14439
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