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Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis

Mastitis is a very common inflammatory disease of the mammary gland of dairy cows, resulting in a reduction of milk production and quality. Probiotics may serve as an alternative to antibiotics to prevent mastitis, and the use of probiotics in this way may lessen the risk of antibiotic resistant bac...

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Autores principales: Urakawa, Megumi, Zhuang, Tao, Sato, Hidetoshi, Takanashi, Satoru, Yoshimura, Kozue, Endo, Yuma, Katsura, Teppei, Umino, Tsuyoshi, Tanaka, Koutaro, Watanabe, Hitoshi, Kobayashi, Hiroko, Takada, Naokazu, Kozutsumi, Tomoyuki, Kumagai, Hiroaki, Asano, Takafumi, Sazawa, Kohko, Ashida, Nobuhisa, Zhao, Guoqi, Rose, Michael T., Kitazawa, Haruki, Shirakawa, Hitoshi, Watanabe, Kouichi, Nochi, Tomonori, Nakamura, Takehiko, Aso, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541589/
https://www.ncbi.nlm.nih.gov/pubmed/36085592
http://dx.doi.org/10.1111/asj.13764
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author Urakawa, Megumi
Zhuang, Tao
Sato, Hidetoshi
Takanashi, Satoru
Yoshimura, Kozue
Endo, Yuma
Katsura, Teppei
Umino, Tsuyoshi
Tanaka, Koutaro
Watanabe, Hitoshi
Kobayashi, Hiroko
Takada, Naokazu
Kozutsumi, Tomoyuki
Kumagai, Hiroaki
Asano, Takafumi
Sazawa, Kohko
Ashida, Nobuhisa
Zhao, Guoqi
Rose, Michael T.
Kitazawa, Haruki
Shirakawa, Hitoshi
Watanabe, Kouichi
Nochi, Tomonori
Nakamura, Takehiko
Aso, Hisashi
author_facet Urakawa, Megumi
Zhuang, Tao
Sato, Hidetoshi
Takanashi, Satoru
Yoshimura, Kozue
Endo, Yuma
Katsura, Teppei
Umino, Tsuyoshi
Tanaka, Koutaro
Watanabe, Hitoshi
Kobayashi, Hiroko
Takada, Naokazu
Kozutsumi, Tomoyuki
Kumagai, Hiroaki
Asano, Takafumi
Sazawa, Kohko
Ashida, Nobuhisa
Zhao, Guoqi
Rose, Michael T.
Kitazawa, Haruki
Shirakawa, Hitoshi
Watanabe, Kouichi
Nochi, Tomonori
Nakamura, Takehiko
Aso, Hisashi
author_sort Urakawa, Megumi
collection PubMed
description Mastitis is a very common inflammatory disease of the mammary gland of dairy cows, resulting in a reduction of milk production and quality. Probiotics may serve as an alternative to antibiotics to prevent mastitis, and the use of probiotics in this way may lessen the risk of antibiotic resistant bacteria developing. We investigated the effect of oral feeding of probiotic Bacillus subtilis (BS) C‐3102 strain on the onset of mastitis in dairy cows with a previous history of mastitis. BS feeding significantly decreased the incidence of mastitis, the average number of medication days and the average number of days when milk was discarded, and maintained the mean SCC in milk at a level substantially lower than the control group. BS feeding was associated with lower levels of cortisol and TBARS and increased the proportion of CD4(+) T cells and CD11c(+) CD172a(high) dendritic cells in the blood by flow cytometry analysis. Parturition increased the migrating frequency of granulocytes toward a milk chemoattractant cyclophilin A in the control cows, however, this was reduced by BS feeding, possibly indicating a decreased sensitivity of peripheral granulocytes to cyclophilin A. These results reveal that B. subtilis C‐3102 has potential as a probiotic and has preventative capacity against mastitis in dairy cows.
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spelling pubmed-95415892022-10-14 Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis Urakawa, Megumi Zhuang, Tao Sato, Hidetoshi Takanashi, Satoru Yoshimura, Kozue Endo, Yuma Katsura, Teppei Umino, Tsuyoshi Tanaka, Koutaro Watanabe, Hitoshi Kobayashi, Hiroko Takada, Naokazu Kozutsumi, Tomoyuki Kumagai, Hiroaki Asano, Takafumi Sazawa, Kohko Ashida, Nobuhisa Zhao, Guoqi Rose, Michael T. Kitazawa, Haruki Shirakawa, Hitoshi Watanabe, Kouichi Nochi, Tomonori Nakamura, Takehiko Aso, Hisashi Anim Sci J Research Articles Mastitis is a very common inflammatory disease of the mammary gland of dairy cows, resulting in a reduction of milk production and quality. Probiotics may serve as an alternative to antibiotics to prevent mastitis, and the use of probiotics in this way may lessen the risk of antibiotic resistant bacteria developing. We investigated the effect of oral feeding of probiotic Bacillus subtilis (BS) C‐3102 strain on the onset of mastitis in dairy cows with a previous history of mastitis. BS feeding significantly decreased the incidence of mastitis, the average number of medication days and the average number of days when milk was discarded, and maintained the mean SCC in milk at a level substantially lower than the control group. BS feeding was associated with lower levels of cortisol and TBARS and increased the proportion of CD4(+) T cells and CD11c(+) CD172a(high) dendritic cells in the blood by flow cytometry analysis. Parturition increased the migrating frequency of granulocytes toward a milk chemoattractant cyclophilin A in the control cows, however, this was reduced by BS feeding, possibly indicating a decreased sensitivity of peripheral granulocytes to cyclophilin A. These results reveal that B. subtilis C‐3102 has potential as a probiotic and has preventative capacity against mastitis in dairy cows. John Wiley and Sons Inc. 2022-09-09 2022-01 /pmc/articles/PMC9541589/ /pubmed/36085592 http://dx.doi.org/10.1111/asj.13764 Text en © 2022 The Authors. Animal Science Journal published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Animal Science. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Urakawa, Megumi
Zhuang, Tao
Sato, Hidetoshi
Takanashi, Satoru
Yoshimura, Kozue
Endo, Yuma
Katsura, Teppei
Umino, Tsuyoshi
Tanaka, Koutaro
Watanabe, Hitoshi
Kobayashi, Hiroko
Takada, Naokazu
Kozutsumi, Tomoyuki
Kumagai, Hiroaki
Asano, Takafumi
Sazawa, Kohko
Ashida, Nobuhisa
Zhao, Guoqi
Rose, Michael T.
Kitazawa, Haruki
Shirakawa, Hitoshi
Watanabe, Kouichi
Nochi, Tomonori
Nakamura, Takehiko
Aso, Hisashi
Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis
title Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis
title_full Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis
title_fullStr Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis
title_full_unstemmed Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis
title_short Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis
title_sort prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic bacillus subtilis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541589/
https://www.ncbi.nlm.nih.gov/pubmed/36085592
http://dx.doi.org/10.1111/asj.13764
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