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Long‐term effects of glucocorticoid excess on the brain
The metabolic and cardiovascular clinical manifestations in patients with Cushing's syndrome (CS) are generally well known. However, recent studies have broadened the perspective of the effects of hypercortisolism, showing that both endogenous and exogenous glucocorticoid excess alter brain fun...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541651/ https://www.ncbi.nlm.nih.gov/pubmed/35980208 http://dx.doi.org/10.1111/jne.13142 |
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author | Dekkers, Alies J. Amaya, Jorge Miguel van der Meulen, Merel Biermasz, Nienke R. Meijer, Onno C. Pereira, Alberto M. |
author_facet | Dekkers, Alies J. Amaya, Jorge Miguel van der Meulen, Merel Biermasz, Nienke R. Meijer, Onno C. Pereira, Alberto M. |
author_sort | Dekkers, Alies J. |
collection | PubMed |
description | The metabolic and cardiovascular clinical manifestations in patients with Cushing's syndrome (CS) are generally well known. However, recent studies have broadened the perspective of the effects of hypercortisolism, showing that both endogenous and exogenous glucocorticoid excess alter brain functioning on several time scales. Consequently, cognitive deficits and neuropsychological symptoms are highly prevalent during both active CS and CS in remission, as well as during glucocorticoid treatment. In this review, we discuss the effects of endogenous hypercortisolism and exogenously induced glucocorticoid excess on the brain, as well as the prevalence of cognitive and neuropsychological deficits and their course after biochemical remission. Furthermore, we propose possible mechanisms that may underly neuronal changes, based on experimental models and in vitro studies. Finally, we offer recommendations for future studies. |
format | Online Article Text |
id | pubmed-9541651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95416512022-10-14 Long‐term effects of glucocorticoid excess on the brain Dekkers, Alies J. Amaya, Jorge Miguel van der Meulen, Merel Biermasz, Nienke R. Meijer, Onno C. Pereira, Alberto M. J Neuroendocrinol Invited Reviews The metabolic and cardiovascular clinical manifestations in patients with Cushing's syndrome (CS) are generally well known. However, recent studies have broadened the perspective of the effects of hypercortisolism, showing that both endogenous and exogenous glucocorticoid excess alter brain functioning on several time scales. Consequently, cognitive deficits and neuropsychological symptoms are highly prevalent during both active CS and CS in remission, as well as during glucocorticoid treatment. In this review, we discuss the effects of endogenous hypercortisolism and exogenously induced glucocorticoid excess on the brain, as well as the prevalence of cognitive and neuropsychological deficits and their course after biochemical remission. Furthermore, we propose possible mechanisms that may underly neuronal changes, based on experimental models and in vitro studies. Finally, we offer recommendations for future studies. John Wiley and Sons Inc. 2022-08-18 2022-08 /pmc/articles/PMC9541651/ /pubmed/35980208 http://dx.doi.org/10.1111/jne.13142 Text en © 2022 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Reviews Dekkers, Alies J. Amaya, Jorge Miguel van der Meulen, Merel Biermasz, Nienke R. Meijer, Onno C. Pereira, Alberto M. Long‐term effects of glucocorticoid excess on the brain |
title | Long‐term effects of glucocorticoid excess on the brain |
title_full | Long‐term effects of glucocorticoid excess on the brain |
title_fullStr | Long‐term effects of glucocorticoid excess on the brain |
title_full_unstemmed | Long‐term effects of glucocorticoid excess on the brain |
title_short | Long‐term effects of glucocorticoid excess on the brain |
title_sort | long‐term effects of glucocorticoid excess on the brain |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541651/ https://www.ncbi.nlm.nih.gov/pubmed/35980208 http://dx.doi.org/10.1111/jne.13142 |
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