Cargando…

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype

BACKGROUND: Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long‐lived immune cells that exert important homeostatic and inflammatory functions which are dysregulated in asthma. Unique...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fricker, Michael, Qin, Ling, Sánchez‐Ovando, Stephany, Simpson, Jodie L., Baines, Katherine J., Riveros, Carlos, Scott, Hayley A., Wood, Lisa G., Wark, Peter AB., Kermani, Nazanin Z., Chung, Kian Fan, Gibson, Peter G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541696/ https://www.ncbi.nlm.nih.gov/pubmed/34510493 http://dx.doi.org/10.1111/all.15087

Ejemplares similares

Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts
por: Sánchez‐Ovando, Stephany, et al.
Publicado: (2022)

Sputum colour can identify patients with neutrophilic inflammation in asthma
por: Pabreja, Kavita, et al.
Publicado: (2017)

Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression
por: Lokwani, Ravi, et al.
Publicado: (2019)

Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques
por: Simpson, Jodie L, et al.
Publicado: (2003)

Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma
por: Niessen, Natalie M., et al.
Publicado: (2021)

Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma
por: Sánchez‐Ovando, Stephany, et al.
Publicado: (2020)

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
por: Kermani, Nazanin Zounemat, et al.
Publicado: (2021)

A Sputum 6 Gene Expression Signature Predicts Inflammatory Phenotypes and Future Exacerbations of COPD
por: Baines, Katherine J, et al.
Publicado: (2020)

Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
por: Kermani, Nazanin Zounemat, et al.
Publicado: (2021)

Hemopexin: A Novel Anti-inflammatory Marker for Distinguishing COPD From Asthma
por: Winter, Natasha A., et al.
Publicado: (2021)

Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma
por: Baines, Katherine J., et al.
Publicado: (2015)

Asthma Endotyping and Biomarkers in Childhood Asthma
por: Licari, Amelia, et al.
Publicado: (2018)

Instability of sputum molecular phenotypes in U-BIOPRED severe asthma
por: Kermani, Nazanin Z., et al.
Publicado: (2021)

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts
por: Beech, Augusta, et al.
Publicado: (2022)

Asthma Endotypes and an Overview of Targeted Therapy for Asthma
por: Svenningsen, Sarah, et al.
Publicado: (2017)

Neutrophil to lymphocyte ratio is a better indicator of COPD exacerbation severity in neutrophilic endotypes than eosinophilic endotypes
por: Aksoy, Emine, et al.
Publicado: (2018)

Phenotypes and endotypes of severe asthma in children
por: Yoo, Young
Publicado: (2013)

Endotyping Asthma: Profiling the Metabolic Dimension?
por: Wilde, Michael J., et al.
Publicado: (2021)

Eosinophilia as a treatable trait in three patients with asthma and COPD
por: Ramsahai, James Michael, et al.
Publicado: (2018)

Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study
por: Lokwani, Ravi, et al.
Publicado: (2019)

A survey of specialist opinions on biomarker use in severe asthma in Australia: scepticism but hope?
por: Ramsahai, J. Michael, et al.
Publicado: (2020)

Arginine metabolic endotypes related to asthma severity
por: Xu, Weiling, et al.
Publicado: (2017)

Defining Pediatric Asthma: Phenotypes to Endotypes and Beyond
por: Conrad, Laura A., et al.
Publicado: (2020)

Novel Biological Therapies for Severe Asthma Endotypes
por: Pelaia, Corrado, et al.
Publicado: (2022)

Discerning asthma endotypes through comorbidity mapping
por: Jia, Gengjie, et al.
Publicado: (2022)

Next steps in precision approaches for asthma-proteomics and asthma endotypes
por: Brasier, Allan R.
Publicado: (2022)

Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD
por: Winter, Natasha A, et al.
Publicado: (2021)

Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD
por: Negewo, Netsanet A, et al.
Publicado: (2016)

Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?
por: Van Hulst, Glenn, et al.
Publicado: (2021)

From spirometry to spatial omics in pursuit of asthma endotypes
por: Hinks, Timothy S. C.
Publicado: (2022)

Eosinophilic Asthma, Phenotypes-Endotypes and Current Biomarkers of Choice
por: Porpodis, Konstantinos, et al.
Publicado: (2022)

Childhood asthma phenotypes and endotypes: a glance into the mosaic
por: Foppiano, Francesco, et al.
Publicado: (2023)

Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD
por: Baines, Katherine J., et al.
Publicado: (2018)

Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD
por: Negewo, Netsanet A, et al.
Publicado: (2017)

Mepolizumab asthma treatment failure due to refractory airway eosinophilia, which responded to benralizumab
por: Cook, Alistair, et al.
Publicado: (2021)

A Prospective Study of Respiratory Viral Infection in Pregnant Women With and Without Asthma
por: Murphy, Vanessa E., et al.
Publicado: (2013)

Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes
por: Papakonstantinou, Eleni, et al.
Publicado: (2021)

Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis
por: Nielsen, Bibi Uhre, et al.
Publicado: (2020)

Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β
por: Gao, Peng, et al.
Publicado: (2015)

Cystic Fibrosis Sputum Impairs the Ability of Neutrophils to Kill Staphylococcus aureus
por: Fantone, Kayla, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f3j57pe175o78mp8ce5u5alq3b