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N‐terminal alterations turn the gut hormone GLP‐2 into an antagonist with gradual loss of GLP‐2 receptor selectivity towards more GLP‐1 receptor interaction

BACKGROUND AND PURPOSE: To fully elucidate the regulatory role of the GLP‐2 system in the gut and the bones, potent and selective GLP‐2 receptor (GLP‐2R) antagonists are needed. Searching for antagonist activity, we performed systematic N‐terminal truncations of human GLP‐2(1‐33). EXPERIMENTAL APPRO...

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Detalles Bibliográficos
Autores principales:	Gabe, Maria Buur Nordskov, Gasbjerg, Lærke Smidt, Gadgaard, Sarina, Lindquist, Peter, Holst, Jens Juul, Rosenkilde, Mette Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541843/ https://www.ncbi.nlm.nih.gov/pubmed/35523760 http://dx.doi.org/10.1111/bph.15866

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