Proton metabolic mapping of the brain at 7 T using a two‐dimensional free induction decay–echo‐planar spectroscopic imaging readout with lipid suppression

The increased signal‐to‐noise ratio (SNR) and chemical shift dispersion at high magnetic fields (≥7 T) have enabled neuro‐metabolic imaging at high spatial resolutions. To avoid very long acquisition times with conventional magnetic resonance spectroscopic imaging (MRSI) phase‐encoding schemes, solutions such as pulse‐acquire or free induction decay (FID) sequences with short repetition time and inner volume selection methods with acceleration (echo‐planar spectroscopic imaging [EPSI]), have been proposed. With the inner volume selection methods, limited spatial coverage of the brain and long echo times may still impede clinical implementation. FID‐MRSI sequences benefit from a short echo time and have a high SNR per time unit; however, contamination from strong extra‐cranial lipid signals remains a problem that can hinder correct metabolite quantification. L2‐regularization can be applied to remove lipid signals in cases with high spatial resolution and accurate prior knowledge. In this work, we developed an accelerated two‐dimensional (2D) FID‐MRSI sequence using an echo‐planar readout and investigated the performance of lipid suppression by L2‐regularization, an external crusher coil, and the combination of these two methods to compare the resulting spectral quality in three subjects. The reduction factor of lipid suppression using the crusher coil alone varies from 2 to 7 in the lipid region of the brain boundary. For the combination of the two methods, the average lipid area inside the brain was reduced by 2% to 38% compared with that of unsuppressed lipids, depending on the subject's region of interest. 2D FID‐EPSI with external lipid crushing and L2‐regularization provides high in‐plane coverage and is suitable for investigating brain metabolite distributions at high fields.