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Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank
AIMS: Myocardial infarction (MI) is among the commonest attributable risk factors for heart failure (HF). We compared clinical characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE cohort and validated our results in UK Biobank. METHODS AND R...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542039/ https://www.ncbi.nlm.nih.gov/pubmed/35365899 http://dx.doi.org/10.1002/ejhf.2495 |
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author | Rastogi, Tripti Ho, Frederick K. Rossignol, Patrick Merkling, Thomas Butler, Javed Clark, Andrew Collier, Timothy Delles, Christian Jukema, J Wouter Heymans, Stephane Latini, Roberto Mebazaa, Alexandre Pellicori, Pierpaolo Sever, Peter Staessen, Jan A. Thijs, Lutgarde Cleland, John G. Sattar, Naveed Zannad, Faiez Girerd, Nicolas |
author_facet | Rastogi, Tripti Ho, Frederick K. Rossignol, Patrick Merkling, Thomas Butler, Javed Clark, Andrew Collier, Timothy Delles, Christian Jukema, J Wouter Heymans, Stephane Latini, Roberto Mebazaa, Alexandre Pellicori, Pierpaolo Sever, Peter Staessen, Jan A. Thijs, Lutgarde Cleland, John G. Sattar, Naveed Zannad, Faiez Girerd, Nicolas |
author_sort | Rastogi, Tripti |
collection | PubMed |
description | AIMS: Myocardial infarction (MI) is among the commonest attributable risk factors for heart failure (HF). We compared clinical characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE cohort and validated our results in UK Biobank. METHODS AND RESULTS: During a follow‐up of 5.2 (3.5–5.9) years, 177 (2.4%) patients with prior MI and 370 (1.92%) patients without prior MI experienced HF onset in the HOMAGE cohort (n = 26 478, history of MI: n = 7241). Older age, male sex and higher heart rate were significant risk factors of HF onset in patients with and without prior MI. Lower renal function was more strongly associated with HF onset in patients with prior MI. Higher body mass index (BMI), systolic blood pressure and blood glucose were significantly associated with HF onset only in patients without prior MI (all p for interactions <0.05). In the UK Biobank (n = 500 001, history of MI: n = 4555), higher BMI, glycated haemoglobin, diabetes and hypertension had a stronger association with HF onset in participants without prior MI compared to participants with MI (all p for interactions <0.05). CONCLUSION: The importance of clinical risk factors associated with HF onset is dependent on whether the patient has had a prior MI. Diabetes and hypertension are associated with new‐onset HF only in the absence of MI history. Patients may benefit from targeted risk management based on MI history. |
format | Online Article Text |
id | pubmed-9542039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95420392022-10-14 Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank Rastogi, Tripti Ho, Frederick K. Rossignol, Patrick Merkling, Thomas Butler, Javed Clark, Andrew Collier, Timothy Delles, Christian Jukema, J Wouter Heymans, Stephane Latini, Roberto Mebazaa, Alexandre Pellicori, Pierpaolo Sever, Peter Staessen, Jan A. Thijs, Lutgarde Cleland, John G. Sattar, Naveed Zannad, Faiez Girerd, Nicolas Eur J Heart Fail Prevention of Hf AIMS: Myocardial infarction (MI) is among the commonest attributable risk factors for heart failure (HF). We compared clinical characteristics associated with the progression to HF in patients with or without a history of MI in the HOMAGE cohort and validated our results in UK Biobank. METHODS AND RESULTS: During a follow‐up of 5.2 (3.5–5.9) years, 177 (2.4%) patients with prior MI and 370 (1.92%) patients without prior MI experienced HF onset in the HOMAGE cohort (n = 26 478, history of MI: n = 7241). Older age, male sex and higher heart rate were significant risk factors of HF onset in patients with and without prior MI. Lower renal function was more strongly associated with HF onset in patients with prior MI. Higher body mass index (BMI), systolic blood pressure and blood glucose were significantly associated with HF onset only in patients without prior MI (all p for interactions <0.05). In the UK Biobank (n = 500 001, history of MI: n = 4555), higher BMI, glycated haemoglobin, diabetes and hypertension had a stronger association with HF onset in participants without prior MI compared to participants with MI (all p for interactions <0.05). CONCLUSION: The importance of clinical risk factors associated with HF onset is dependent on whether the patient has had a prior MI. Diabetes and hypertension are associated with new‐onset HF only in the absence of MI history. Patients may benefit from targeted risk management based on MI history. John Wiley & Sons, Ltd. 2022-04-18 2022-06 /pmc/articles/PMC9542039/ /pubmed/35365899 http://dx.doi.org/10.1002/ejhf.2495 Text en © 2022 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Prevention of Hf Rastogi, Tripti Ho, Frederick K. Rossignol, Patrick Merkling, Thomas Butler, Javed Clark, Andrew Collier, Timothy Delles, Christian Jukema, J Wouter Heymans, Stephane Latini, Roberto Mebazaa, Alexandre Pellicori, Pierpaolo Sever, Peter Staessen, Jan A. Thijs, Lutgarde Cleland, John G. Sattar, Naveed Zannad, Faiez Girerd, Nicolas Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank |
title | Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank |
title_full | Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank |
title_fullStr | Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank |
title_full_unstemmed | Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank |
title_short | Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank |
title_sort | comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from homage and the uk biobank |
topic | Prevention of Hf |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542039/ https://www.ncbi.nlm.nih.gov/pubmed/35365899 http://dx.doi.org/10.1002/ejhf.2495 |
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