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Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review
Dengue is a vector-borne disease caused by the dengue virus (DENV) and is a major health concern worldwide, particularly in regions of endemic disease. Dengue usually presents as a self-limited febrile illness. In some cases, more severe forms with hemorrhage and shock can occur, and children are es...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542041/ https://www.ncbi.nlm.nih.gov/pubmed/36225478 http://dx.doi.org/10.7759/cureus.28916 |
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author | Foucambert, Paul Esbrand, Faith D Zafar, Sana Panthangi, Venkatesh Cyril Kurupp, Adrienne R Raju, Anjumol Luthra, Gaurav Shahbaz, Mahrukh Almatooq, Halah Khan, Safeera |
author_facet | Foucambert, Paul Esbrand, Faith D Zafar, Sana Panthangi, Venkatesh Cyril Kurupp, Adrienne R Raju, Anjumol Luthra, Gaurav Shahbaz, Mahrukh Almatooq, Halah Khan, Safeera |
author_sort | Foucambert, Paul |
collection | PubMed |
description | Dengue is a vector-borne disease caused by the dengue virus (DENV) and is a major health concern worldwide, particularly in regions of endemic disease. Dengue usually presents as a self-limited febrile illness. In some cases, more severe forms with hemorrhage and shock can occur, and children are especially prone to develop it. These forms can be lethal without appropriate management, and no antiviral treatment exists today. In the absence of a curative treatment for dengue, its clinical prevention remains essential. One vaccine - the chimeric yellow fever-dengue-tetravalent dengue vaccine (CYD-TDV) - has been approved for use in some populations, and several others are currently in development, including Takeda's tetravalent dengue vaccine candidate (TAK-003). This study is a systematic review of the current literature realized to evaluate the efficacy of the dengue vaccines in preventing severe dengue in children. This review focuses on the vaccines CYD-TDV and TAK-003. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, PubMed Central (PMC), Medical Literature Analysis and Retrieval System Online (MEDLINE), Cochrane Library, and Google Scholar were the databases used to find the relevant data. The articles were selected using specific inclusion and exclusion criteria, and quality appraisal was realized with standardized quality assessment tools. Overall, our study shows that the dengue vaccines CYD-TDV and TAK-003 confer protection against severe dengue in children. Some distinctions exist depending on the vaccine type, the age, and the dengue serostatus of patients. While demonstrating encouraging results, this review also emphasizes the need for more in-depth studies about the safety and efficacy of dengue vaccines. |
format | Online Article Text |
id | pubmed-9542041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-95420412022-10-11 Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review Foucambert, Paul Esbrand, Faith D Zafar, Sana Panthangi, Venkatesh Cyril Kurupp, Adrienne R Raju, Anjumol Luthra, Gaurav Shahbaz, Mahrukh Almatooq, Halah Khan, Safeera Cureus Pediatrics Dengue is a vector-borne disease caused by the dengue virus (DENV) and is a major health concern worldwide, particularly in regions of endemic disease. Dengue usually presents as a self-limited febrile illness. In some cases, more severe forms with hemorrhage and shock can occur, and children are especially prone to develop it. These forms can be lethal without appropriate management, and no antiviral treatment exists today. In the absence of a curative treatment for dengue, its clinical prevention remains essential. One vaccine - the chimeric yellow fever-dengue-tetravalent dengue vaccine (CYD-TDV) - has been approved for use in some populations, and several others are currently in development, including Takeda's tetravalent dengue vaccine candidate (TAK-003). This study is a systematic review of the current literature realized to evaluate the efficacy of the dengue vaccines in preventing severe dengue in children. This review focuses on the vaccines CYD-TDV and TAK-003. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, PubMed Central (PMC), Medical Literature Analysis and Retrieval System Online (MEDLINE), Cochrane Library, and Google Scholar were the databases used to find the relevant data. The articles were selected using specific inclusion and exclusion criteria, and quality appraisal was realized with standardized quality assessment tools. Overall, our study shows that the dengue vaccines CYD-TDV and TAK-003 confer protection against severe dengue in children. Some distinctions exist depending on the vaccine type, the age, and the dengue serostatus of patients. While demonstrating encouraging results, this review also emphasizes the need for more in-depth studies about the safety and efficacy of dengue vaccines. Cureus 2022-09-07 /pmc/articles/PMC9542041/ /pubmed/36225478 http://dx.doi.org/10.7759/cureus.28916 Text en Copyright © 2022, Foucambert et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pediatrics Foucambert, Paul Esbrand, Faith D Zafar, Sana Panthangi, Venkatesh Cyril Kurupp, Adrienne R Raju, Anjumol Luthra, Gaurav Shahbaz, Mahrukh Almatooq, Halah Khan, Safeera Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review |
title | Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review |
title_full | Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review |
title_fullStr | Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review |
title_full_unstemmed | Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review |
title_short | Efficacy of Dengue Vaccines in the Prevention of Severe Dengue in Children: A Systematic Review |
title_sort | efficacy of dengue vaccines in the prevention of severe dengue in children: a systematic review |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542041/ https://www.ncbi.nlm.nih.gov/pubmed/36225478 http://dx.doi.org/10.7759/cureus.28916 |
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