Mass Spectrometry Detection and Imaging of a Non‐Covalent Protein–Drug Complex in Tissue from Orally Dosed Rats

Here, we demonstrate detection by mass spectrometry of an intact protein–drug complex directly from liver tissue from rats that had been orally dosed with the drug. The protein–drug complex comprised fatty acid binding protein 1, FABP1, non‐covalently bound to the small molecule therapeutic bezafibr...

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Detalles Bibliográficos
Autores principales: Illes‐Toth, Eva, Hale, Oliver J., Hughes, James W., Strittmatter, Nicole, Rose, Jonathan, Clayton, Ben, Sargeant, Rebecca, Jones, Stewart, Dannhorn, Andreas, Goodwin, Richard J. A., Cooper, Helen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542108/
https://www.ncbi.nlm.nih.gov/pubmed/35830332
http://dx.doi.org/10.1002/anie.202202075

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