Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases

The gastrointestinal tract is the largest compartment of the body's immune system exposed to microorganisms, structural components and metabolites, antigens derived from the diet, and pathogens. Most studies have focused on immune responses in the stomach, the small intestine, and the colon, bu...

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Autores principales: Kaymak, Tanay, Hruz, Petr, Niess, Jan Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
State‐of‐the‐Art Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542113/
https://www.ncbi.nlm.nih.gov/pubmed/34213831
http://dx.doi.org/10.1111/febs.16103
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author Kaymak, Tanay
Hruz, Petr
Niess, Jan Hendrik
author_facet Kaymak, Tanay
Hruz, Petr
Niess, Jan Hendrik
author_sort Kaymak, Tanay
collection PubMed
description The gastrointestinal tract is the largest compartment of the body's immune system exposed to microorganisms, structural components and metabolites, antigens derived from the diet, and pathogens. Most studies have focused on immune responses in the stomach, the small intestine, and the colon, but the esophagus has remained an understudied anatomic immune segment. Here, we discuss the esophagus' anatomical and physiological distinctions that may account for inflammatory esophageal diseases.
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spelling pubmed-95421132022-10-14 Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases Kaymak, Tanay Hruz, Petr Niess, Jan Hendrik FEBS J State‐of‐the‐Art Reviews The gastrointestinal tract is the largest compartment of the body's immune system exposed to microorganisms, structural components and metabolites, antigens derived from the diet, and pathogens. Most studies have focused on immune responses in the stomach, the small intestine, and the colon, but the esophagus has remained an understudied anatomic immune segment. Here, we discuss the esophagus' anatomical and physiological distinctions that may account for inflammatory esophageal diseases. John Wiley and Sons Inc. 2021-07-13 2022-08 /pmc/articles/PMC9542113/ /pubmed/34213831 http://dx.doi.org/10.1111/febs.16103 Text en © 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle State‐of‐the‐Art Reviews
Kaymak, Tanay
Hruz, Petr
Niess, Jan Hendrik
Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
title Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
title_full Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
title_fullStr Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
title_full_unstemmed Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
title_short Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
title_sort immune system and microbiome in the esophagus: implications for understanding inflammatory diseases
topic State‐of‐the‐Art Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542113/
https://www.ncbi.nlm.nih.gov/pubmed/34213831
http://dx.doi.org/10.1111/febs.16103
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