A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma

AIMS: Inherited or somatic mutations in the MRE11, RAD50 and NBN genes increase the incidence of tumours, including medulloblastoma (MB). On the other hand, MRE11, RAD50 and NBS1 protein components of the MRN complex are often overexpressed and sometimes essential in cancer. In order to solve the ap...

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Detalles Bibliográficos
Autores principales: Petroni, Marialaura, Fabretti, Francesca, Di Giulio, Stefano, Nicolis di Robilant, Vittoria, La Monica, Veronica, Moretti, Marta, Belardinilli, Francesca, Bufalieri, Francesca, Coppa, Anna, Paci, Paola, Corsi, Alessandro, De Smaele, Enrico, Coni, Sonia, Canettieri, Gianluca, Di Marcotullio, Lucia, Wang, Zhao‐Qi, Giannini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542137/
https://www.ncbi.nlm.nih.gov/pubmed/35839783
http://dx.doi.org/10.1111/nan.12837

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