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Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis

BACKGROUND: Extracorporeal photopheresis (ECP) is a blood‐based therapeutic procedure increasingly used for modulation of immune dysregulation in various underlying disease settings. The aim of this study was to compare the procedure times and blood collection efficiencies between the two approaches...

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Autores principales: Mayer, Wolfgang, Kontekakis, Antonis, Maas, Christopher, Kuchenbecker, Ulrike, Behlke, Susanne, Schennach, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542192/
https://www.ncbi.nlm.nih.gov/pubmed/35225372
http://dx.doi.org/10.1002/jca.21974
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author Mayer, Wolfgang
Kontekakis, Antonis
Maas, Christopher
Kuchenbecker, Ulrike
Behlke, Susanne
Schennach, Harald
author_facet Mayer, Wolfgang
Kontekakis, Antonis
Maas, Christopher
Kuchenbecker, Ulrike
Behlke, Susanne
Schennach, Harald
author_sort Mayer, Wolfgang
collection PubMed
description BACKGROUND: Extracorporeal photopheresis (ECP) is a blood‐based therapeutic procedure increasingly used for modulation of immune dysregulation in various underlying disease settings. The aim of this study was to compare the procedure times and blood collection efficiencies between the two approaches currently utilized in European centers: the integrated versus the multistep nonintegrated procedures. METHODS: A retrospective data analysis was conducted, comparing treatment data from patients who received ECP therapy at the Central Institute for Blood Transfusion & Department of Immunology (ZIB) of the Tirol Kliniken GmbH, where the integrated and multistep nonintegrated procedures are routinely used in an approximated setup. RESULTS: During the observation period, a total of 15 patients who were treated with alternating systems on 2 consecutive days were identified. This allowed treatment pair comparisons with minimal interpatient variabilities, similar to a cross‐over design even though analyzed retrospectively. Total average procedure times with the integrated system were 99.3 vs 122.0 minutes with the multistep nonintegrated procedures, respectively. Significant differences were observed for all steps of the ECP procedure: (a) time for buffy coat collection, 66.5 vs 74.7; (b) handling/transfer, 2.8 vs 18.7; (c) irradiation, 20.3 vs 11.7; and (d) reinfusion/handling time, 9.6 vs 16.3 minutes. The calculated collection throughput was 7.79 mL/min for the integrated and 7.84 mL/min for the multistep nonintegrated procedures, and with a white blood cell (WBC) collection efficiency of 34.2% and 21.0%, respectively. CONCLUSION: The data presented in this study show a significant shorter overall procedure time and higher WBC collection efficiency for the integrated ECP system.
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spelling pubmed-95421922022-10-14 Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis Mayer, Wolfgang Kontekakis, Antonis Maas, Christopher Kuchenbecker, Ulrike Behlke, Susanne Schennach, Harald J Clin Apher Research Articles BACKGROUND: Extracorporeal photopheresis (ECP) is a blood‐based therapeutic procedure increasingly used for modulation of immune dysregulation in various underlying disease settings. The aim of this study was to compare the procedure times and blood collection efficiencies between the two approaches currently utilized in European centers: the integrated versus the multistep nonintegrated procedures. METHODS: A retrospective data analysis was conducted, comparing treatment data from patients who received ECP therapy at the Central Institute for Blood Transfusion & Department of Immunology (ZIB) of the Tirol Kliniken GmbH, where the integrated and multistep nonintegrated procedures are routinely used in an approximated setup. RESULTS: During the observation period, a total of 15 patients who were treated with alternating systems on 2 consecutive days were identified. This allowed treatment pair comparisons with minimal interpatient variabilities, similar to a cross‐over design even though analyzed retrospectively. Total average procedure times with the integrated system were 99.3 vs 122.0 minutes with the multistep nonintegrated procedures, respectively. Significant differences were observed for all steps of the ECP procedure: (a) time for buffy coat collection, 66.5 vs 74.7; (b) handling/transfer, 2.8 vs 18.7; (c) irradiation, 20.3 vs 11.7; and (d) reinfusion/handling time, 9.6 vs 16.3 minutes. The calculated collection throughput was 7.79 mL/min for the integrated and 7.84 mL/min for the multistep nonintegrated procedures, and with a white blood cell (WBC) collection efficiency of 34.2% and 21.0%, respectively. CONCLUSION: The data presented in this study show a significant shorter overall procedure time and higher WBC collection efficiency for the integrated ECP system. John Wiley & Sons, Inc. 2022-02-28 2022-08 /pmc/articles/PMC9542192/ /pubmed/35225372 http://dx.doi.org/10.1002/jca.21974 Text en © 2022 Therakos UK Ltd. Journal of Clinical Apheresis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Mayer, Wolfgang
Kontekakis, Antonis
Maas, Christopher
Kuchenbecker, Ulrike
Behlke, Susanne
Schennach, Harald
Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
title Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
title_full Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
title_fullStr Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
title_full_unstemmed Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
title_short Comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
title_sort comparison of procedure times and collection efficiencies using integrated and multistep nonintegrated procedures for extracorporeal photopheresis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542192/
https://www.ncbi.nlm.nih.gov/pubmed/35225372
http://dx.doi.org/10.1002/jca.21974
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