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The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
INTRODUCTION: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. METHODS: Multicenter brain magnetic r...
Autores principales: | Salvadó, Gemma, Ferreira, Daniel, Operto, Grégory, Cumplido‐Mayoral, Irene, Arenaza‐Urquijo, Eider M., Cacciaglia, Raffaele, Falcon, Carles, Vilor‐Tejedor, Natàlia, Minguillon, Carolina, Groot, Colin, van der Flier, Wiesje M., Barkhof, Frederik, Scheltens, Philip, Ossenkoppele, Rik, Kern, Silke, Zettergren, Anna, Skoog, Ingmar, Hort, Jakub, Stomrud, Erik, van Westen, Danielle, Hansson, Oskar, Molinuevo, José Luis, Wahlund, Lars‐Olof, Westman, Eric, Gispert, Juan Domingo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542211/ https://www.ncbi.nlm.nih.gov/pubmed/34877786 http://dx.doi.org/10.1002/alz.12487 |
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