2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids

Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation of a new optically active inositol phosphate derivat...

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Autores principales: Sangiorgio, Sara, Cambò, Mattia, Semproli, Riccardo, Ubiali, Daniela, Speranza, Giovanna, Rabuffetti, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Special Issue: Chirality in Pharmaceutical Research and Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542212/
https://www.ncbi.nlm.nih.gov/pubmed/35531652
http://dx.doi.org/10.1002/chir.23457
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author Sangiorgio, Sara
Cambò, Mattia
Semproli, Riccardo
Ubiali, Daniela
Speranza, Giovanna
Rabuffetti, Marco
author_facet Sangiorgio, Sara
Cambò, Mattia
Semproli, Riccardo
Ubiali, Daniela
Speranza, Giovanna
Rabuffetti, Marco
author_sort Sangiorgio, Sara
collection PubMed
description Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation of a new optically active inositol phosphate derivative, 2‐O‐acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate (6), and its characterization by spectroscopic methods. Compound (6) represents a useful intermediate for the preparation of inositol phosphate and phospholipids, in particular of glycerophosphoinositol (GPI), a natural anti‐inflammatory agent.
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spelling pubmed-95422122022-10-14 2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids Sangiorgio, Sara Cambò, Mattia Semproli, Riccardo Ubiali, Daniela Speranza, Giovanna Rabuffetti, Marco Chirality Special Issue: Chirality in Pharmaceutical Research and Development Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation of a new optically active inositol phosphate derivative, 2‐O‐acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate (6), and its characterization by spectroscopic methods. Compound (6) represents a useful intermediate for the preparation of inositol phosphate and phospholipids, in particular of glycerophosphoinositol (GPI), a natural anti‐inflammatory agent. John Wiley and Sons Inc. 2022-05-09 2022-08 /pmc/articles/PMC9542212/ /pubmed/35531652 http://dx.doi.org/10.1002/chir.23457 Text en © 2022 The Authors. Chirality published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Special Issue: Chirality in Pharmaceutical Research and Development
Sangiorgio, Sara
Cambò, Mattia
Semproli, Riccardo
Ubiali, Daniela
Speranza, Giovanna
Rabuffetti, Marco
2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
title 2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
title_full 2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
title_fullStr 2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
title_full_unstemmed 2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
title_short 2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
title_sort 2‐o‐acetyl‐3,4,5,6‐tetra‐o‐benzyl‐d‐myo‐inosityl diphenylphosphate: a new useful intermediate to inositol phosphate and phospholipids
topic Special Issue: Chirality in Pharmaceutical Research and Development
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542212/
https://www.ncbi.nlm.nih.gov/pubmed/35531652
http://dx.doi.org/10.1002/chir.23457
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