Cytochrome P450(Blt) Enables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks

We report our investigation of the utility of peptide crosslinking cytochrome P450 enzymes from biarylitide biosynthesis to generate a range of cyclic tripeptides from simple synthons. The crosslinked tripeptides produced by this P450 include both tyrosine‐histidine (A−N−B) and tyrosine‐tryptophan (...

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Detalles Bibliográficos
Autores principales: Zhao, Yongwei, Marschall, Edward, Treisman, Maxine, McKay, Alasdair, Padva, Leo, Crüsemann, Max, Nelson, David R., Steer, David L., Schittenhelm, Ralf B., Tailhades, Julien, Cryle, Max J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542247/
https://www.ncbi.nlm.nih.gov/pubmed/35851739
http://dx.doi.org/10.1002/anie.202204957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542247/
https://www.ncbi.nlm.nih.gov/pubmed/35851739
http://dx.doi.org/10.1002/anie.202204957

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