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High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting
Next-generation sequencing data is fundamentally changing the clinical management of patients with cancer. The most frequent genomic alterations in malignancy are mutations and amplifications, with a subset of tumors having multiple amplifications – “amplificators”. We sought to understand the molec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542347/ https://www.ncbi.nlm.nih.gov/pubmed/36171565 http://dx.doi.org/10.1080/15384047.2022.2128608 |