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Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight?
In the context of ACTH‐dependent Cushing's syndrome, ectopic ACTH secretion from a neuroendocrine tumour is not uncommon, and needs to be carefully differentiated from pituitary‐dependent Cushing's syndrome, Cushing's disease, in order to optimise therapy. Some cases may be quite obvi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542389/ https://www.ncbi.nlm.nih.gov/pubmed/35980277 http://dx.doi.org/10.1111/jne.13137 |
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author | Hayes, Aimee R. Grossman, Ashley B. |
author_facet | Hayes, Aimee R. Grossman, Ashley B. |
author_sort | Hayes, Aimee R. |
collection | PubMed |
description | In the context of ACTH‐dependent Cushing's syndrome, ectopic ACTH secretion from a neuroendocrine tumour is not uncommon, and needs to be carefully differentiated from pituitary‐dependent Cushing's syndrome, Cushing's disease, in order to optimise therapy. Some cases may be quite obvious, while in others the diagnosis may be difficult to confirm and the source of ACTH problematic, as many clinical and biochemical tests may overlap with Cushing's disease. Imaging is essential, but needs to be interpreted in the light of both anatomical as well as functional imaging modalities. In this review we summarise some of the main diagnostic problems, and emphasise the multimodal and interdisciplinary nature of the diagnostic pathways. |
format | Online Article Text |
id | pubmed-9542389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95423892022-10-14 Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? Hayes, Aimee R. Grossman, Ashley B. J Neuroendocrinol Editor Invited Review In the context of ACTH‐dependent Cushing's syndrome, ectopic ACTH secretion from a neuroendocrine tumour is not uncommon, and needs to be carefully differentiated from pituitary‐dependent Cushing's syndrome, Cushing's disease, in order to optimise therapy. Some cases may be quite obvious, while in others the diagnosis may be difficult to confirm and the source of ACTH problematic, as many clinical and biochemical tests may overlap with Cushing's disease. Imaging is essential, but needs to be interpreted in the light of both anatomical as well as functional imaging modalities. In this review we summarise some of the main diagnostic problems, and emphasise the multimodal and interdisciplinary nature of the diagnostic pathways. John Wiley and Sons Inc. 2022-08-18 2022-08 /pmc/articles/PMC9542389/ /pubmed/35980277 http://dx.doi.org/10.1111/jne.13137 Text en © 2022 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Editor Invited Review Hayes, Aimee R. Grossman, Ashley B. Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? |
title | Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? |
title_full | Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? |
title_fullStr | Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? |
title_full_unstemmed | Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? |
title_short | Distinguishing Cushing's disease from the ectopic ACTH syndrome: Needles in a haystack or hiding in plain sight? |
title_sort | distinguishing cushing's disease from the ectopic acth syndrome: needles in a haystack or hiding in plain sight? |
topic | Editor Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542389/ https://www.ncbi.nlm.nih.gov/pubmed/35980277 http://dx.doi.org/10.1111/jne.13137 |
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