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Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene, encoding G protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2), have been linked with increased electroencephalographic frontal theta event-related oscillations (ERO) in subjects diagnosed with alcoh...

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Detalles Bibliográficos
Autores principales: Popova, Dina, Gameiro-Ros, Isabel, Youssef, Mark M., Zalamea, Petronio, Morris, Ayeshia D., Prytkova, Iya, Jadali, Azadeh, Kwan, Kelvin Y., Kamarajan, Chella, Salvatore, Jessica E., Xuei, Xiaoling, Chorlian, David B., Porjesz, Bernice, Kuperman, Samuel, Dick, Danielle M., Goate, Alison, Edenberg, Howard J., Tischfield, Jay A., Pang, Zhiping P., Slesinger, Paul A., Hart, Ronald P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542475/
https://www.ncbi.nlm.nih.gov/pubmed/36207584
http://dx.doi.org/10.1038/s41380-022-01818-x