Cargando…

Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of X-Linked Adrenoleukodystrophy

X-linked adrenoleukodystrophy (ALD) is a genetic disorder that presents neurologically as either a rapid and fatal cerebral demyelinating disease in childhood (childhood cerebral adrenoleukodystrophy; ccALD) or slow degeneration of the spinal cord in adulthood (adrenomyeloneuropathy; AMN). All forms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nemeth, Christina L., Gӧk, Özgül, Tomlinson, Sophia N., Sharma, Anjali, Moser, Ann B., Kannan, Sujatha, Kannan, Rangaramanujam M., Fatemi, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542479/ https://www.ncbi.nlm.nih.gov/pubmed/36207570 http://dx.doi.org/10.1007/s13311-022-01311-x

Ejemplares similares

Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics
por: Sharma, Anjali, et al.
Publicado: (2018)

Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation
por: Zhang, Fan, et al.
Publicado: (2016)

Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation
por: Sharma, Rishi, et al.
Publicado: (2018)

Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration
por: Liaw, Kevin, et al.
Publicado: (2020)

Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma
por: Liaw, Kevin, et al.
Publicado: (2020)

Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy
por: Sah, Nirnath, et al.
Publicado: (2023)

Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model
por: Zhang, Zhi, et al.
Publicado: (2020)

Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders
por: Sharma, Anjali, et al.
Publicado: (2020)

Dendrimer-Based N-Acetyl Cysteine Maternal Therapy Ameliorates Placental Inflammation via Maintenance of M1/M2 Macrophage Recruitment
por: Liu, Yang, et al.
Publicado: (2022)

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture
por: Alnasser, Yossef, et al.
Publicado: (2018)

Systemic Dendrimer-Peptide Therapies for Wet Age-Related Macular Degeneration
por: Wu, Tony, et al.
Publicado: (2023)

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome
por: Khoury, Elizabeth Smith, et al.
Publicado: (2020)

Galactosylated hydroxyl‐polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning‐induced liver failure
por: Porterfield, Joshua E., et al.
Publicado: (2023)

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome
por: Nance, Elizabeth, et al.
Publicado: (2017)

Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator
por: Gondcaille, Catherine, et al.
Publicado: (2005)

Correction to: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome
por: Nance, Elizabeth, et al.
Publicado: (2018)

Systemic administration of dendrimer N‐acetyl cysteine improves outcomes and survival following cardiac arrest
por: Modi, Hiren R., et al.
Publicado: (2021)

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice
por: Tallon, Carolyn, et al.
Publicado: (2022)

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis
por: Hollinger, Kristen R., et al.
Publicado: (2022)

Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes
por: Matsukawa, Takashi, et al.
Publicado: (2010)

X-Linked Adrenoleukodystrophy: Molecular and Functional Analysis of the ABCD1 Gene in Argentinean Patients
por: Amorosi, Cyntia Anabel, et al.
Publicado: (2012)

Dendrimer Brain Uptake and Targeted Therapy for Brain Injury in a Large Animal Model of Hypothermic Circulatory Arrest
por: Mishra, Manoj K., et al.
Publicado: (2014)

Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury
por: Lei, Jun, et al.
Publicado: (2017)

Nanomedicine in cerebral palsy
por: Balakrishnan, Bindu, et al.
Publicado: (2013)

A Korean boy with atypical X-linked adrenoleukodystrophy confirmed by an unpublished mutation of ABCD1
por: Jwa, Hye Jeong, et al.
Publicado: (2014)

Mutations of ABCD1 gene and phenotype of Vietnamese patients with X-linked adrenoleukodystrophy (X-ALD)
por: Dung, Vu Chi, et al.
Publicado: (2013)

S149R, a novel mutation in the ABCD1 gene causing X-linked adrenoleukodystrophy
por: Yan, Fang, et al.
Publicado: (2017)

Successful Pregnancy Following Preimplantation Genetic Diagnosis of Adrenoleukodystrophy by Detection of Mutation on the ABCD1 Gene
por: Trinh The, Son, et al.
Publicado: (2021)

X-linked adrenoleukodystrophy caused by maternal ABCD1 mutation and paternal X chromosome inactivation
por: Li, Zhen, et al.
Publicado: (2022)

Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy
por: Guo, Yan, et al.
Publicado: (2016)

Preferential expression of mutant ABCD1 allele is common in adrenoleukodystrophy female carriers but unrelated to clinical symptoms
por: Salsano, Ettore, et al.
Publicado: (2012)

Evaluation of Retinoids for Induction of the Redundant Gene ABCD2 as an Alternative Treatment Option in X-Linked Adrenoleukodystrophy
por: Weber, Franziska D., et al.
Publicado: (2014)

Identification of Two Novel Mutations of ABCD1 Gene in Pedigrees with X-Linked Adrenoleukodystrophy and Review of the Literature
por: Dong, Bingzi, et al.
Publicado: (2022)

Two Single Nucleotide Deletions in the ABCD1 Gene Causing Distinct Phenotypes of X-Linked Adrenoleukodystrophy
por: Dohr, Katrin A., et al.
Publicado: (2023)

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies
por: Turk, Bela R., et al.
Publicado: (2020)

ABCD2 Is a Direct Target of β-Catenin and TCF-4: Implications for X-Linked Adrenoleukodystrophy Therapy
por: Park, Chul-Yong, et al.
Publicado: (2013)

A novel mutation in the ABCD1 gene of a Moroccan patient with X-linked adrenoleukodystrophy: case report
por: Karkar, Adnane, et al.
Publicado: (2015)

An ABCD1 Mutation (c.253dupC) Caused Diverse Phenotypes of Adrenoleukodystrophy in an Iranian Consanguineous Pedigree
por: Mehrpour, Masoud, et al.
Publicado: (2016)

A novel mutation in the ABCD1 gene of a Chinese patient with X-linked adrenoleukodystrophy: Case report
por: Wang, Jing, et al.
Publicado: (2018)

Novel ABCD1 Gene Mutation in a Korean Patient with X-Linked Adrenoleukodystrophy Presenting with Addison's Disease
por: Cho, Yun Kyung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kpb062gpndfsjootdaicnmv3n3