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Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block

Most patients with spasticity, rigidity, and other symptoms of the upper motor neuron syndrome respond effectively to surgical treatment with an intrathecal baclofen pump when their symptoms become intractable to nonsurgical measures. Baclofen administered into the lumbar subarachnoid space produces...

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Detalles Bibliográficos
Autores principales: Scerrati, Alba, De Bonis, Pasquale, Norri, Nicolò, Cavallo, Michele Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association of Neurological Surgeons 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542496/
https://www.ncbi.nlm.nih.gov/pubmed/36285267
http://dx.doi.org/10.3171/2020.7.FOCVID2021
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author Scerrati, Alba
De Bonis, Pasquale
Norri, Nicolò
Cavallo, Michele Alessandro
author_facet Scerrati, Alba
De Bonis, Pasquale
Norri, Nicolò
Cavallo, Michele Alessandro
author_sort Scerrati, Alba
collection PubMed
description Most patients with spasticity, rigidity, and other symptoms of the upper motor neuron syndrome respond effectively to surgical treatment with an intrathecal baclofen pump when their symptoms become intractable to nonsurgical measures. Baclofen administered into the lumbar subarachnoid space produces a locally high concentration at the spinal level and a low concentration supraspinally, avoiding most of the central side effects associated with a high oral dose, such as drowsiness and confusion. The aim of surgical treatment is to provide the appropriate volume and concentration of the drug in the subarachnoid space, avoiding the main surgical complications, that is, infections, skin erosion, and catheter displacement. The video can be found here: https://youtu.be/HetelPwwwak
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spelling pubmed-95424962022-10-24 Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block Scerrati, Alba De Bonis, Pasquale Norri, Nicolò Cavallo, Michele Alessandro Neurosurg Focus Video Article Most patients with spasticity, rigidity, and other symptoms of the upper motor neuron syndrome respond effectively to surgical treatment with an intrathecal baclofen pump when their symptoms become intractable to nonsurgical measures. Baclofen administered into the lumbar subarachnoid space produces a locally high concentration at the spinal level and a low concentration supraspinally, avoiding most of the central side effects associated with a high oral dose, such as drowsiness and confusion. The aim of surgical treatment is to provide the appropriate volume and concentration of the drug in the subarachnoid space, avoiding the main surgical complications, that is, infections, skin erosion, and catheter displacement. The video can be found here: https://youtu.be/HetelPwwwak American Association of Neurological Surgeons 2020-10-01 /pmc/articles/PMC9542496/ /pubmed/36285267 http://dx.doi.org/10.3171/2020.7.FOCVID2021 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the CC BY-NC-ND license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Scerrati, Alba
De Bonis, Pasquale
Norri, Nicolò
Cavallo, Michele Alessandro
Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
title Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
title_full Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
title_fullStr Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
title_full_unstemmed Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
title_short Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
title_sort surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542496/
https://www.ncbi.nlm.nih.gov/pubmed/36285267
http://dx.doi.org/10.3171/2020.7.FOCVID2021
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