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Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block
Most patients with spasticity, rigidity, and other symptoms of the upper motor neuron syndrome respond effectively to surgical treatment with an intrathecal baclofen pump when their symptoms become intractable to nonsurgical measures. Baclofen administered into the lumbar subarachnoid space produces...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association of Neurological Surgeons
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542496/ https://www.ncbi.nlm.nih.gov/pubmed/36285267 http://dx.doi.org/10.3171/2020.7.FOCVID2021 |
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author | Scerrati, Alba De Bonis, Pasquale Norri, Nicolò Cavallo, Michele Alessandro |
author_facet | Scerrati, Alba De Bonis, Pasquale Norri, Nicolò Cavallo, Michele Alessandro |
author_sort | Scerrati, Alba |
collection | PubMed |
description | Most patients with spasticity, rigidity, and other symptoms of the upper motor neuron syndrome respond effectively to surgical treatment with an intrathecal baclofen pump when their symptoms become intractable to nonsurgical measures. Baclofen administered into the lumbar subarachnoid space produces a locally high concentration at the spinal level and a low concentration supraspinally, avoiding most of the central side effects associated with a high oral dose, such as drowsiness and confusion. The aim of surgical treatment is to provide the appropriate volume and concentration of the drug in the subarachnoid space, avoiding the main surgical complications, that is, infections, skin erosion, and catheter displacement. The video can be found here: https://youtu.be/HetelPwwwak |
format | Online Article Text |
id | pubmed-9542496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association of Neurological Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-95424962022-10-24 Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block Scerrati, Alba De Bonis, Pasquale Norri, Nicolò Cavallo, Michele Alessandro Neurosurg Focus Video Article Most patients with spasticity, rigidity, and other symptoms of the upper motor neuron syndrome respond effectively to surgical treatment with an intrathecal baclofen pump when their symptoms become intractable to nonsurgical measures. Baclofen administered into the lumbar subarachnoid space produces a locally high concentration at the spinal level and a low concentration supraspinally, avoiding most of the central side effects associated with a high oral dose, such as drowsiness and confusion. The aim of surgical treatment is to provide the appropriate volume and concentration of the drug in the subarachnoid space, avoiding the main surgical complications, that is, infections, skin erosion, and catheter displacement. The video can be found here: https://youtu.be/HetelPwwwak American Association of Neurological Surgeons 2020-10-01 /pmc/articles/PMC9542496/ /pubmed/36285267 http://dx.doi.org/10.3171/2020.7.FOCVID2021 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the CC BY-NC-ND license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Scerrati, Alba De Bonis, Pasquale Norri, Nicolò Cavallo, Michele Alessandro Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
title | Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
title_full | Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
title_fullStr | Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
title_full_unstemmed | Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
title_short | Surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
title_sort | surgical treatment of spasticity: intrathecal baclofen pump implantation under subarachnoid block |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542496/ https://www.ncbi.nlm.nih.gov/pubmed/36285267 http://dx.doi.org/10.3171/2020.7.FOCVID2021 |
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