Memory B cells and long-lived plasma cells in AMR

Antibody-mediated rejection (AMR) has a strongly negative impact on long-term renal allograft survival. Currently, no recognized effective treatments are available, especially for chronic antibody-mediated rejection (CAMR). Donor-specific antibodies (DSAs) secreted by long-lived plasma cells and mem...

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Detalles Bibliográficos
Autores principales: Yue, Wenlong, Liu, Jia, Li, Xiaohu, Wang, Luman, Li, Jinfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
State-of-the-Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542532/
https://www.ncbi.nlm.nih.gov/pubmed/36190837
http://dx.doi.org/10.1080/0886022X.2022.2128374
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author Yue, Wenlong
Liu, Jia
Li, Xiaohu
Wang, Luman
Li, Jinfeng
author_facet Yue, Wenlong
Liu, Jia
Li, Xiaohu
Wang, Luman
Li, Jinfeng
author_sort Yue, Wenlong
collection PubMed
description Antibody-mediated rejection (AMR) has a strongly negative impact on long-term renal allograft survival. Currently, no recognized effective treatments are available, especially for chronic antibody-mediated rejection (CAMR). Donor-specific antibodies (DSAs) secreted by long-lived plasma cells and memory B cells are acknowledged as biomarkers of AMR. Nevertheless, it may be too late for the DSA routine examination production since DSAs may have binded to graft vascular endothelial cells through complement-dependent or complement-independent pathways. Therefore, methods to effectively monitor memory B cells and long-lived plasma cells and subsequently prevent DSA production are key to reducing the adverse effects of AMR. Therefore, this review mainly summarizes the production pathways of memory B cells and long-lived plasma cells and provides suggestions for the prevention of AMR after transplantation.
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spelling pubmed-95425322022-10-08 Memory B cells and long-lived plasma cells in AMR Yue, Wenlong Liu, Jia Li, Xiaohu Wang, Luman Li, Jinfeng Ren Fail State-of-the-Art Review Antibody-mediated rejection (AMR) has a strongly negative impact on long-term renal allograft survival. Currently, no recognized effective treatments are available, especially for chronic antibody-mediated rejection (CAMR). Donor-specific antibodies (DSAs) secreted by long-lived plasma cells and memory B cells are acknowledged as biomarkers of AMR. Nevertheless, it may be too late for the DSA routine examination production since DSAs may have binded to graft vascular endothelial cells through complement-dependent or complement-independent pathways. Therefore, methods to effectively monitor memory B cells and long-lived plasma cells and subsequently prevent DSA production are key to reducing the adverse effects of AMR. Therefore, this review mainly summarizes the production pathways of memory B cells and long-lived plasma cells and provides suggestions for the prevention of AMR after transplantation. Taylor & Francis 2022-10-03 /pmc/articles/PMC9542532/ /pubmed/36190837 http://dx.doi.org/10.1080/0886022X.2022.2128374 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle State-of-the-Art Review
Yue, Wenlong
Liu, Jia
Li, Xiaohu
Wang, Luman
Li, Jinfeng
Memory B cells and long-lived plasma cells in AMR
title Memory B cells and long-lived plasma cells in AMR
title_full Memory B cells and long-lived plasma cells in AMR
title_fullStr Memory B cells and long-lived plasma cells in AMR
title_full_unstemmed Memory B cells and long-lived plasma cells in AMR
title_short Memory B cells and long-lived plasma cells in AMR
title_sort memory b cells and long-lived plasma cells in amr
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542532/
https://www.ncbi.nlm.nih.gov/pubmed/36190837
http://dx.doi.org/10.1080/0886022X.2022.2128374
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