Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

The gastrointestinal (GI) tract is the reservoir for multidrug resistant (MDR) pathogens, specifically carbapenem-resistant (CR) Klebsiella pneumoniae and other Enterobacteriaceae, which often lead to the spread of antimicrobial resistance genes, severe extraintestinal infections, and lethal outcome...

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Detalles Bibliográficos
Autores principales: Mortzfeld, Benedikt M., Palmer, Jacob D., Bhattarai, Shakti K., Dupre, Haley L., Mercado-Lubio, Regino, Silby, Mark W., Bang, Corinna, McCormick, Beth A., Bucci, Vanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542533/
https://www.ncbi.nlm.nih.gov/pubmed/36175830
http://dx.doi.org/10.1080/19490976.2022.2127633

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