Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila

microRNAs are short noncoding RNAs that buffer fluctuations in gene expression in a myriad of physiological conditions. Here, we carried out a screen to identify the role of microRNAs in the maintenance of age-dependent neuronal functions in adult Drosophila. We report that miR-190 acts in the neuro...

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Detalles Bibliográficos
Autores principales: Fernandes, Jervis, Varghese, Jishy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542781/
https://www.ncbi.nlm.nih.gov/pubmed/36178157
http://dx.doi.org/10.1080/15476286.2022.2127544
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author Fernandes, Jervis
Varghese, Jishy
author_facet Fernandes, Jervis
Varghese, Jishy
author_sort Fernandes, Jervis
collection PubMed
description microRNAs are short noncoding RNAs that buffer fluctuations in gene expression in a myriad of physiological conditions. Here, we carried out a screen to identify the role of microRNAs in the maintenance of age-dependent neuronal functions in adult Drosophila. We report that miR-190 acts in the neurons to regulate lifespan, neuronal maintanence and age-related locomotor activity specifically in male flies. miR-190, a highly conserved microRNA, shows higher expression levels in male flies. Our data suggest that miR-190 functions by regulating target genes that are involved in maintaining neuronal activity and lifespan in male flies.
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spelling pubmed-95427812022-10-08 Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila Fernandes, Jervis Varghese, Jishy RNA Biol Short Communication microRNAs are short noncoding RNAs that buffer fluctuations in gene expression in a myriad of physiological conditions. Here, we carried out a screen to identify the role of microRNAs in the maintenance of age-dependent neuronal functions in adult Drosophila. We report that miR-190 acts in the neurons to regulate lifespan, neuronal maintanence and age-related locomotor activity specifically in male flies. miR-190, a highly conserved microRNA, shows higher expression levels in male flies. Our data suggest that miR-190 functions by regulating target genes that are involved in maintaining neuronal activity and lifespan in male flies. Taylor & Francis 2022-09-30 /pmc/articles/PMC9542781/ /pubmed/36178157 http://dx.doi.org/10.1080/15476286.2022.2127544 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Fernandes, Jervis
Varghese, Jishy
Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
title Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
title_full Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
title_fullStr Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
title_full_unstemmed Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
title_short Sexually dimorphic microRNA miR-190 regulates lifespan in male Drosophila
title_sort sexually dimorphic microrna mir-190 regulates lifespan in male drosophila
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542781/
https://www.ncbi.nlm.nih.gov/pubmed/36178157
http://dx.doi.org/10.1080/15476286.2022.2127544
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