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Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)

INTRODUCTION: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfu...

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Autores principales: Anthon, Carl Thomas, Pène, Frédéric, Perner, Anders, Azoulay, Elie, Puxty, Kathryn, Van De Louw, Andry, Barratt‐Due, Andreas, Chawla, Sanjay, Castro, Pedro, Povoa, Pedro, Coelho, Luis, Metaxa, Victoria, Munshi, Laveena, Kochanek, Matthias, Liebregts, Tobias, Kander, Thomas, Hästbacka, Johanna, Møller, Morten Hylander, Russell, Lene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542787/
https://www.ncbi.nlm.nih.gov/pubmed/36054145
http://dx.doi.org/10.1111/aas.14124
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author Anthon, Carl Thomas
Pène, Frédéric
Perner, Anders
Azoulay, Elie
Puxty, Kathryn
Van De Louw, Andry
Barratt‐Due, Andreas
Chawla, Sanjay
Castro, Pedro
Povoa, Pedro
Coelho, Luis
Metaxa, Victoria
Munshi, Laveena
Kochanek, Matthias
Liebregts, Tobias
Kander, Thomas
Hästbacka, Johanna
Møller, Morten Hylander
Russell, Lene
author_facet Anthon, Carl Thomas
Pène, Frédéric
Perner, Anders
Azoulay, Elie
Puxty, Kathryn
Van De Louw, Andry
Barratt‐Due, Andreas
Chawla, Sanjay
Castro, Pedro
Povoa, Pedro
Coelho, Luis
Metaxa, Victoria
Munshi, Laveena
Kochanek, Matthias
Liebregts, Tobias
Kander, Thomas
Hästbacka, Johanna
Møller, Morten Hylander
Russell, Lene
author_sort Anthon, Carl Thomas
collection PubMed
description INTRODUCTION: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. METHODS: We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count < 150 × 10(9)/L) at baseline and/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life‐support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90‐day mortality using logistic regression analyses. CONCLUSION: The outlined international PLOT‐ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice.
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spelling pubmed-95427872022-10-14 Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU) Anthon, Carl Thomas Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Barratt‐Due, Andreas Chawla, Sanjay Castro, Pedro Povoa, Pedro Coelho, Luis Metaxa, Victoria Munshi, Laveena Kochanek, Matthias Liebregts, Tobias Kander, Thomas Hästbacka, Johanna Møller, Morten Hylander Russell, Lene Acta Anaesthesiol Scand Special Articles INTRODUCTION: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. METHODS: We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count < 150 × 10(9)/L) at baseline and/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life‐support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90‐day mortality using logistic regression analyses. CONCLUSION: The outlined international PLOT‐ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice. John Wiley and Sons Inc. 2022-08-23 2022-10 /pmc/articles/PMC9542787/ /pubmed/36054145 http://dx.doi.org/10.1111/aas.14124 Text en © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Special Articles
Anthon, Carl Thomas
Pène, Frédéric
Perner, Anders
Azoulay, Elie
Puxty, Kathryn
Van De Louw, Andry
Barratt‐Due, Andreas
Chawla, Sanjay
Castro, Pedro
Povoa, Pedro
Coelho, Luis
Metaxa, Victoria
Munshi, Laveena
Kochanek, Matthias
Liebregts, Tobias
Kander, Thomas
Hästbacka, Johanna
Møller, Morten Hylander
Russell, Lene
Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)
title Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)
title_full Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)
title_fullStr Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)
title_full_unstemmed Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)
title_short Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT‐ICU)
title_sort platelet transfusions and thrombocytopenia in intensive care units: protocol for an international inception cohort study (plot‐icu)
topic Special Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542787/
https://www.ncbi.nlm.nih.gov/pubmed/36054145
http://dx.doi.org/10.1111/aas.14124
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